905858-53-9Relevant articles and documents
Solid-phase synthesis and pharmacological evaluation of a library of peptidomimetics as potential farnesyltransferase inhibitors: an approach to new lead compounds
Gilleron,Millet,Houssin,Wlodarczyk,Farce,Lemoine,Goossens,Chavatte,Pommery,Henichart
, p. 745 - 755 (2007/10/03)
Oncogenic Ras proteins whose activation is farnesylation by farnesyltransferase have been seen as important targets for novel anticancer drugs. Inhibitors of this enzyme have already been developed as potential anti-cancer drugs, particularly by rational