905966-41-8 Usage
Description
[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]acetonitrile(SALTDATA: FREE), also known as a boronic acid derivative, is a chemical compound with the formula C14H17BNO. It is characterized by the presence of a boron atom and a phenyl group, making it a versatile reagent in various chemical processes.
Uses
Used in Organic Synthesis:
[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]acetonitrile(SALTDATA: FREE) is used as a reagent in organic synthesis for its ability to participate in Suzuki-Miyaura cross-coupling reactions. These reactions are significant in the synthesis of pharmaceuticals and agrochemicals, allowing for the creation of complex molecular structures with potential applications in medicine and agriculture.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, [4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]acetonitrile(SALTDATA: FREE) serves as a valuable building block for the development of new drugs. Its unique structure allows for the formation of diverse chemical entities that can be tailored to target specific biological pathways or receptors, potentially leading to the discovery of novel therapeutic agents.
Used as a Solvent:
The acetonitrile group in [4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]acetonitrile(SALTDATA: FREE) makes it a useful solvent in various chemical reactions. Its properties enable it to dissolve a wide range of substances, facilitating reactions and improving overall yields in the synthesis of target compounds.
Used in Chemical Research:
[4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl]acetonitrile(SALTDATA: FREE) is also utilized in chemical research to explore new reaction pathways, develop innovative synthetic methods, and understand the fundamental principles governing chemical interactions. Its diverse applications in research contribute to the advancement of knowledge in the field of chemistry and related disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 905966-41-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,5,9,6 and 6 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 905966-41:
(8*9)+(7*0)+(6*5)+(5*9)+(4*6)+(3*6)+(2*4)+(1*1)=198
198 % 10 = 8
So 905966-41-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H16BNO2/c1-13(2)9-16-14(17-10-13)12-5-3-11(4-6-12)7-8-15/h3-6H,7,9-10H2,1-2H3
905966-41-8Relevant articles and documents
Ni(COD)2/PCy3 catalyzed cross-coupling of aryl and heteroaryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates in THF at room temperature
Leowanawat, Pawaret,Zhang, Na,Resmerita, Ana-Maria,Rosen, Brad M.,Percec, Virgil
experimental part, p. 9946 - 9955 (2012/01/15)
Reaction conditions for the Ni(COD)2/PCy3 catalyzed cross-coupling of aryl neopentylglycolboronates with aryl mesylates were developed. By using optimized reaction conditions, Ni(COD)2/PCy 3 was shown to be a versatile catalyst for the cross-coupling of a diversity of aryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates containing both electron-donating and electron-withdrawing substituents in their para, ortho, and meta positions in THF at room temperature. This Ni-catalyzed cross-coupling of aryl neopentylglycolboronates is also effective for the synthesis of heterobiaryls and biaryls containing electrophilic functionalities sensitive to organolithium and organomagnesium derivatives. In combination with the recently developed Nicatalyzed neopentylglycolborylation, all Ni-catalyzed routes to functional biaryls and heterobiaryls are now easily accessible (Figure presented).
Neopentylglycolborylation of aryl chlorides catalyzed by the mixed ligand system NiCl2(dppp)/dppf
Moldoveanu, Costel,Wilson, Daniela A.,Wilson, Christopher J.,Corcoran, Patrick,Rosen, Brad M.,Percec, Virgil
supporting information; experimental part, p. 4974 - 4977 (2010/01/16)
The mixed ligand system 10 mol % NICl2(dppp) with 5 mol % dppf was discovered to be an extremely efficient catalyst for the neopentylglycolborylation of a diversity of electron-rich and electron-deficient aryl chlorides. Optimization showed tha
