906069-48-5

Basic information

• Product Name: 4-Thiazolidinecarboxylic acid, 2,2-dimethyl-3-[oxo(2,4,6-trimethylphenyl)acetyl]-, (4R)-
• CAS NO: 906069-48-5
• Molecular Formula: C17H21NO4S
• Molecular Weight: 335.424
• Mol File: 906069-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Thiazolidinecarboxylic acid, 2,2-dimethyl-3-[oxo(2,4,6-trimethylphenyl)acetyl]-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolidinecarboxylic acid, 2,2-dimethyl-3-[oxo(2,4,6-trimethylphenyl)acetyl]-, (4R)-(906069-48-5)
• EPA Substance Registry System: 4-Thiazolidinecarboxylic acid, 2,2-dimethyl-3-[oxo(2,4,6-trimethylphenyl)acetyl]-, (4R)-(906069-48-5)

Safety Data

• Hazardous Substances Data: 906069-48-5(Hazardous Substances Data)

Upstream product

• 533933-48-1 ethyl(2R)-5,5-dimethyl-1-(1,2-dioxo-2-ethoxyethyl)-2-(4-thiazolidine)carboxylate 
• 906069-47-4 (R)-2,2-Dimethyl-3-[2-oxo-2-(2,4,6-trimethyl-phenyl)-acetyl]-thiazolidine-4-carboxylic acid ethyl ester 

Relevant articles and documents

FK506-binding protein ligands: Structure-based design, synthesis, and neurotrophic/neuroprotective properties of substituted 5,5-dimethyl-2-(4- thiazolidine)carboxylates

Structure-based design and discovery of novel neuroimmunophilin FK506-binding protein (FKBP) ligands were pursued in the present study. The binding mode of the known FKBP ligand 1 (3-(3-pyridyl)-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate) in complex with FKBP12 was investigated using LUDI simulation and upon which a novel scaffold structure predicted to possess improved binding affinity was designed. A virtual combinatorial library composed of diverse combinations of two substituted groups was constructed using Project Library, followed by an automated screening of the library against the ligand binding site on FKBP52 using DOCK. Forty-three candidate compounds that displayed favorable binding with the receptor were identified and synthesized. The neurotrophic activity of the candidate compounds was evaluated on chick dorsal root ganglion cultures in vitro. As a result, 15 compounds exhibited positive effects on ganglion neurite outgrowth in the presence of 0.15 ng/mL NGF, among which 7 compounds at testing concentrations of 1 pM and 100 pM showed greater efficacy than 1 at 100 pM. Compound 18 (3-(3-pyridyl)-1-propyl (2S)-5,5-dimethyl-1-(3,3-dimethyl-1,2- dioxobutyl)-2-(4-thiazolidine)carboxylate) afforded the most potent effect in promoting the processes of neurite outgrowth and which was in a concentration-dependent manner from 1 pM to 100 pM. Half-maximal effect occurred at about 10 pM. Moreover, 18 at a dosage of 10 mg/kg was found to be significantly neuroprotective in a mouse peripheral sympathetic nerve injury model induced by 8 mg/kg 6-hydroxydopamine. This study further suggests the clinical potential of novel FKBP ligands as a new therapeutic approach in the treatment of neurodegenerative disorders, such as Parkinson's disease.