906351-28-8Relevant articles and documents
Tetracycline analogues with a selective inhibitory effect on HIF-1α
Bendiabdellah,Rahman,Uranchimeg,Nahar,Antonow,Shoemaker,Melillo,Zinzalla,Thurston
, p. 923 - 926 (2014/07/08)
As part of a programme to discover novel transcription factor inhibitors, a 40-membered library of tetracycline analogues was screened to identify potential HIF-1 inhibitors. Two novel analogues (5b and 5c) with significant HIF-1 modulation properties were identified. These molecules possess good cellular penetration properties, and provide significant down-regulation of VEGF in U251 cells.