90724-59-7

Basic information

• Product Name: 4-Thiazolemethanol,acetate(ester)(9CI)
• Synonyms: 4-Thiazolemethanol,acetate(ester)(9CI)
• CAS NO: 90724-59-7
• Molecular Formula: C6H7NO2S
• Molecular Weight: 0
• Product Categories: THIAZOLE
• Mol File: 90724-59-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Thiazolemethanol,acetate(ester)(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thiazolemethanol,acetate(ester)(9CI)(90724-59-7)
• EPA Substance Registry System: 4-Thiazolemethanol,acetate(ester)(9CI)(90724-59-7)

Safety Data

• Hazardous Substances Data: 90724-59-7(Hazardous Substances Data)

Upstream product

• 3364-76-9 4-chloromethylthiazole 
• 7036-04-6 1,3-thiazol-4-ylmethanol 
• 108-24-7 acetic anhydride 

Downstream Products

• 7036-04-6 1,3-thiazol-4-ylmethanol 

Relevant articles and documents

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins

A streamlined total synthesis of N14-desacetoxytubulysin H (Tb1) based on a C-H activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described. Applications of the developed synthetic strategies and technologies to the synthesis of a series of tubulysin analogues (Tb2-Tb41 and PTb-D42) are also reported. Biological evaluation of the synthesized compounds against an array of cancer cells revealed a number of novel analogues (e.g., Tb14), some with exceptional potencies against certain cell lines [e.g., Tb32 with IC50 = 12 pM against MES SA (uterine sarcoma) cell line and 2 pM against HEK 293T (human embryonic kidney) cell line], and a set of valuable structure-activity relationships. The highly potent cytotoxic compounds discovered in this study are highly desirable as payloads for antibody-drug conjugates and other drug delivery systems for personalized targeted cancer chemotherapies.