90726-50-4 Usage
Description
4-(2-Piperidyl)-1-butanol, also known as N-(2-Hydroxyethyl)piperidine, is a primary alcohol and an organic compound. It is a colorless liquid with a slightly unpleasant odor and is soluble in water. This chemical is commonly used as a precursor in the synthesis of pharmaceutical drugs and as a chiral building block in organic synthesis due to its unique structure and properties.
Uses
Used in Pharmaceutical Synthesis:
4-(2-Piperidyl)-1-butanol is used as a precursor in the synthesis of pharmaceutical drugs, such as the antihistamine hydroxyzine. Its unique structure and properties make it a valuable component in the development of various medications.
Used in Organic Synthesis:
4-(2-Piperidyl)-1-butanol is used as a chiral building block in organic synthesis. Its unique structure allows it to be a key component in the creation of various organic compounds.
Used in Asymmetric Catalysis:
4-(2-Piperidyl)-1-butanol has been studied for its potential use as a chiral ligand in asymmetric catalysis. Its unique properties make it a promising candidate for enhancing the selectivity and efficiency of catalytic reactions in the chemical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 90726-50-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,7,2 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 90726-50:
(7*9)+(6*0)+(5*7)+(4*2)+(3*6)+(2*5)+(1*0)=134
134 % 10 = 4
So 90726-50-4 is a valid CAS Registry Number.
90726-50-4Relevant articles and documents
Highly Regioselective α-Addition of Alkynyl and Alkenyl Grignard Reagents to 1-Alkoxycarbonylpyridinium Salts and Its Application to Synthesis of 1-Azabicycloalkanes and (+/-)-Solenopsin A
Yamaguchi, Ryohei,Nakazono, Yutaka,Matsuki, Toshitsugu,Hata, Ei-ichiro,Kawanisi, Mituyosi
, p. 215 - 222 (2007/10/02)
Nucleophilic addition of a variety of alkynyl and alkenyl Grignard reagents to 1-methoxycarbonylpyridinium chloride takes place at the α-position in a highly regioselective manner to give 2-substituted 1-methoxycarbonyl-1,2-dihydropyridines exclusively, while, with alkyl Grignard reagents, a lack of the regioselectivity is observed.These results may be explained by the HSAB principle.The high α-regioselectivity is preserved in the cases of 2-substituted pyridines as well, giving 2,6-disubstituted 1,2-dihydropyridines exclusively, which can be transformed stereoselectively into cis- and trans-2,6-dialkylated piperidines.These highly regioselective α-alkynylations of 1-methoxycarbonylpyridinium salts are exploited in synthesis of 1-azabicycloalkanes as well as (+/-)-solenopsin A.
