9074-14-0 Usage
Description
RYNTR, also known as Thioredoxin Reductase from rat liver, is an enzyme that plays a crucial role in maintaining the redox balance within cells. It possesses reducing capacity and is involved in various cellular processes, making it a valuable tool for scientific research and potential therapeutic applications.
Uses
Used in Pharmaceutical Research:
RYNTR is used as a research tool for studying the uptake and reduction of a-lipoic acid by utilizing the reducing capacity of human erythrocytes. This helps in understanding the mechanisms of a-lipoic acid and its potential therapeutic applications.
Used in Biochemical Research:
RYNTR is used as a research tool for studying the activation mechanism of transglutaminase 2 (TG2) in the extracellular matrix by using Thioredoxin. This aids in understanding the role of TG2 in various biological processes and its potential as a therapeutic target.
Biochem/physiol Actions
Thioredoxin reductase (TrxR) is a NADPH-dependent oxidoreductase containing one FAD per subunit that reduces the active site disulfide in oxidized thioredoxin (Trx). The molecular weight of the isozymes from mammalian sources vary between 55-67 kDa as compared with 35 kDa in prokaryotes, plants or yeast. The substrate specificity of the mammalian enzyme is much broader than the prokaryotic enzyme reducing both mammalian and E. coli thioredoxins as well as non-disulfide substrates such selenite, lipoic acids, lipid hydroperoxides, and hydrogen peroxide.
Check Digit Verification of cas no
The CAS Registry Mumber 9074-14-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 9,0,7 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 9074-14:
(6*9)+(5*0)+(4*7)+(3*4)+(2*1)+(1*4)=100
100 % 10 = 0
So 9074-14-0 is a valid CAS Registry Number.