90797-73-2

Basic information

• Product Name: 2-Thiazolamine, 5-(4-chlorophenyl)-4-methyl-
• CAS NO: 90797-73-2
• Molecular Formula: C10H9ClN2S
• Molecular Weight: 224.714
• Mol File: 90797-73-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Thiazolamine, 5-(4-chlorophenyl)-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiazolamine, 5-(4-chlorophenyl)-4-methyl-(90797-73-2)
• EPA Substance Registry System: 2-Thiazolamine, 5-(4-chlorophenyl)-4-methyl-(90797-73-2)

Safety Data

• Hazardous Substances Data: 90797-73-2(Hazardous Substances Data)

Upstream product

• 17356-08-0 thiourea 
• 142528-63-0 3-(4-chlorophenyl)-2-methyl-2-nitrooxirane 
• 420-04-2 CYANAMID 
• 5586-88-9 1-(4-chlorophenyl)propan-2-one 
• 104-88-1 4-chlorobenzaldehyde 
• 29805-11-6 1-(4-chlorophenyl)prop-2-yn-1-ol 

Relevant articles and documents

Synthetic method of 4,5-disubstituted-2-aminothiazole compound

The invention discloses a synthetic method of a 4,5-disubstituted-2-aminothiazole compound. The synthetic method sequentially comprises the following steps: 1) making a nitro-epoxy compound react withammonium thiocyanate in the presence of a solvent and an alkali catalyst at the temperature of 40-/+5 DEG C for 10 to 14 hours; 2) adding water into reaction liquid prepared in the step 1), extracting the mixture with ethyl acetate, washing a prepared organic layer, drying the organic layer, and performing concentration with a rotary evaporator; 3) performing silica gel column chromatography on the concentrate prepared in the step 2) to obtain the 4,5-disubstituted-2-aminothiazole compound. The method for synthesizing the 4,5-disubstituted-2-aminothiazole compound disclosed by the invention has the characteristics of adoption of readily-available raw materials, mild reaction conditions, high yield, convenience in post treatment and the like.

One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles

Substituted 2-aminothiazoles have been synthesized from α-nitro-epoxides, cyanamide, and sodium sulfide through a facile, three-component, and ecofriendly protocol with good to excellent yields. This reaction was achieved at room temperature without any additives. A possible mechanism has also been proposed.

Preparation method of 4,5-disubstituted-2-substituted aminothiazole compound

The invention discloses a preparation method of a 4,5-disubstituted-2-substituted aminothiazole compound. The preparation method comprises steps as follows: 1), nitro epoxy compounds and thiourea compounds react at the room temperature for 4-8 h in the pr