90799-83-0

Basic information

• Product Name: 2-amino-5-[(4-chlorophenyl)thio]-4(3H)-pyrimidone
• Synonyms: 2-amino-5-[(4-chlorophenyl)thio]-4(3H)-pyrimidone
• CAS NO: 90799-83-0
• Molecular Weight: 253.712
• Mol File: 90799-83-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-5-[(4-chlorophenyl)thio]-4(3H)-pyrimidone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-[(4-chlorophenyl)thio]-4(3H)-pyrimidone(90799-83-0)
• EPA Substance Registry System: 2-amino-5-[(4-chlorophenyl)thio]-4(3H)-pyrimidone(90799-83-0)

Safety Data

• Hazardous Substances Data: 90799-83-0(Hazardous Substances Data)

Upstream product

• 61937-71-1 2-amino-5-bromo-1H-pyrimidin-6-one 
• 106-54-7 p-Chlorothiophenol 

Downstream Products

• 93864-11-0 2-amino-5-[(4-chlorophenyl)thio]-4-morpholinopyrimidine 

Relevant articles and documents

An improved synthesis of 2-amino-5-[(4-chlorophenyl)thio]4- morpholinopyrimidine (BW 394U) - A potential antisenility agent

This paper describes the synthesis of 2-amino-5-[(4-chlorophenyl)thio]- 4-morpholinopyrimidine (BW 394U, compound 4), a potential antisenility agent. The key intermediates 3a/3b were obtained from an in situ-generated Vilsmeier-Haack reagent that simultaneously protected the 2-amino group prior to further manipulations. Displacement of the chloro group in 3a gave 4 in 40% yield and 4-dimethylamino analogue 5. However, displacement of 3b with morpholine followed by treatment with aqueous base gave 4 in 74% yield.