908119-67-5

Basic information

• Product Name: 2-(2-iodophenoxy)-1-(4-methoxyphenyl)ethan-1-one
• Synonyms: 2-(2-iodophenoxy)-1-(4-methoxyphenyl)ethan-1-one
• CAS NO: 908119-67-5
• Molecular Weight: 368.171
• Mol File: 908119-67-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(2-iodophenoxy)-1-(4-methoxyphenyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-iodophenoxy)-1-(4-methoxyphenyl)ethan-1-one(908119-67-5)
• EPA Substance Registry System: 2-(2-iodophenoxy)-1-(4-methoxyphenyl)ethan-1-one(908119-67-5)

Safety Data

• Hazardous Substances Data: 908119-67-5(Hazardous Substances Data)

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 533-58-4 2-Iodophenol 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 1346667-97-7 1-(4-methoxyphenyl)-2-(2-p-tolylethynylphenoxy)ethanone 
• 1346667-94-4 1-(4-methoxyphenyl)-2-(2-(phenylethynyl)phenoxy)ethan-1-one 
• 1346668-03-8 2-(4-methoxybenzoyl)-3-(4-methylbenzyl)benzofuran 
• 1346668-00-5 3-benzyl-2-(4-methoxybenzoyl)-benzofuran 
• 1258932-56-7 (6H-benzo[c]chromen-6-yl)(4-methoxyphenyl)methanone 
• 923595-00-0 C₁₅H₁₅BO₅ 
• 923594-94-9 2-(2-iodophenoxymethyl)-2-(4-methoxyphenyl)-1,3-dioxolane 
• 57664-71-8 3-(4'-methoxyphenyl)benzofuran 

Relevant articles and documents

Halogen-metal exchange/cyclization of iodoketones: A direct synthesis of 3-arylbenzofurans

The first synthesis of benzofuran 2 was achieved in 17% overall yield in seven steps. The key step was a halogen-metal exchange/cyclization reaction. Several examples of this reaction were reported. Georg Thieme Verlag Stuttgart.

Nickel-Catalyzed Asymmetric Addition of Aromatic Halides to Ketones: Highly Enantioselective Synthesis of Chiral 2,3-Dihydrobenzofurans Containing a Tertiary Alcohol

A highly enantioselective and straightforward synthetic procedure to chiral 3-hydroxy-2,3-dihydrobenzofurans has been developed by nickel/bisoxazoline-catalyzed intramolecular asymmetric addition of aryl halides to unactivated ketones, giving 2,3-dihydrobenzofurans with a chiral tertiary alcohol at the C-3 position in good yields and excellent enantioselectivities (up to 92percent yield and 98percent ee). The gram-scale reaction also proceeded smoothly without a loss of yield and enantioselectivity.

tert-BuOK-mediated carbanion-yne intramolecular cyclization: Synthesis of 2-substituted 3-benzylbenzofurans

A mild, efficient, and regioselective carbanion-yne intramolecular cyclization mediated by t-BuOK for the synthesis of 2-substituted 3-benzylbenzofurans is developed. It was started from o-iodophenol (1), based on O-alkylation, and the Sonogashira reaction in sequence to produce 2-(2-phenylethynylphenoxy)-1-arylalkanones (5). An intramolecular carbanion-yne 5-exo-dig cyclization reaction of 5, which was mediated by t-BuOK, yielded title benzofurans in good yields.