90834-19-8Relevant articles and documents
Rapid Access of Alkynyl and Alkenyl Coumarins via a Dipyridinium Methylide and Propargylamine Cascade Reaction
He, Xinwei,Li, Ruxue,Choy, Pui Ying,Liu, Tianyi,Yuen, On Ying,Leung, Man Pan,Shang, Yongjia,Kwong, Fuk Yee
, p. 7348 - 7352 (2020/10/02)
A DMAP-catalyzed cascade approach allowing facile assembly of alkynyl coumarins is reported. By virtue of reactive o-AQM (in situ generated from modular propargylamine) and a new synthetic equivalent of acyl carbene (from pyridinium ylide), the reaction proceeds smoothly to afford a variety of alkynyl coumarins in good-to-excellent yields. This transition-metal-free and oxidant-free process features moderate functional group tolerance, particularly the-Br group; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of coumarin triflates. This versatile method is also found to be applicable to the preparation of β-alkenyl coumarins, resembling the outcomes of the current Heck-type coupling reaction.
Pd/Indanone-Based Ligands: An Efficient Catalyst System for Ullmann-Type, Suzuki-Miyaura, and Mizoroki-Heck Cross-Coupling Reactions with Aryl Tosylates and Aryl Halides
Waheed, Mohammed,Ahmed, Naseem
, p. 4372 - 4382 (2017/09/12)
2-Hydroxyindan-1-ones have been efficiently synthesized and successfully applied as ligands in Pd-catalyzed Ullmann type, Suzuki-Miyaura, and Mizoroki-Heck cross-coupling reactions with aryl tosylates and aryl halides. The ligands are air- and moisture-stable and have shown high catalytic activity with Pd(OAc) 2 in these cross-coupling reactions. The system tolerates a variety of functional groups in the product and can be re-used at least three times with maximum efficiency..
Resin-bound (succinimid-1-yloxycarbonylmethyl)triphenylphosphonium ylide - A synthon for rapid access to diverse heterocycles under microwave heating
Henkel, Bernd
, p. 355 - 358 (2008/09/16)
The synthesis of a novel and versatile resin-bound (succinimid-1- yloxycarbonylmethyl)triphenylphosphonium ylide is described. The use of this resin to the synthesis of several diverse heterocycles, whilst allowing for ease of workup, is reported. Georg Thieme Verlag Stuttgart.