908351-78-0Relevant articles and documents
Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles
Lee, Chang-Sun,Liu, Weili,Sprengeler, Paul A.,Somoza, John R.,Janc, James W.,Sperandio, David,Spencer, Jeffrey R.,Green, Michael J.,McGrath, Mary E.
, p. 4036 - 4040 (2007/10/03)
A series of novel α-keto-[1,2,4]-oxadiazoles has been synthesized as human tryptase inhibitors for evaluation as a new class of anti-asthmatic agent. The inhibitor design is focused on using a prime-side hydrophobic pocket and the S2 pocket of β-tryptase