908365-91-3

Basic information

• Product Name: (2S,5S)-N-benzoyl-5-(di(ethoxycarbonyl)methyl)-pyrrolidine-2-carboxylic acid ethyl ester
• Synonyms: (2S,5S)-N-benzoyl-5-(di(ethoxycarbonyl)methyl)-pyrrolidine-2-carboxylic acid ethyl ester
• CAS NO: 908365-91-3
• Molecular Weight: 405.448
• Mol File: 908365-91-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2S,5S)-N-benzoyl-5-(di(ethoxycarbonyl)methyl)-pyrrolidine-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5S)-N-benzoyl-5-(di(ethoxycarbonyl)methyl)-pyrrolidine-2-carboxylic acid ethyl ester(908365-91-3)
• EPA Substance Registry System: (2S,5S)-N-benzoyl-5-(di(ethoxycarbonyl)methyl)-pyrrolidine-2-carboxylic acid ethyl ester(908365-91-3)

Safety Data

• Hazardous Substances Data: 908365-91-3(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 675588-10-0 (2S)-5-(di(ethoxycarbonyl)methyl)-pyrrolidine-2-carboxylic acid ethyl ester 
• 675588-12-2 (S)-N-benzoyl-5-(di(ethoxycarbonyl)methylidene)-pyrrolidine-2-carboxylic acid ethyl ester 
• 80442-95-1 ethyl (2S)-5-thioxo-3,4-dihydro-5H-pyrrole-2-carboxylate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 675588-09-7 (S)-5-(di(ethoxycarbonyl)methylidene)-pyrrolidine-2-carboxylic acid ethyl ester 

Downstream Products

• 908366-29-0 (2S,5S)-N-benzoyl-5-(1,1-di(ethoxycarbonyl)ethyl)-pyrrolidine-2-carboxylic acid ethyl ester 

Relevant articles and documents

2,5-Disubstituted pyrrolidines: Synthesis by enamine reduction and subsequent regioselective and diastereoselective alkylations

Methodology for the diastereoselective synthesis of 2,5-disubstituted pyrrolidines by reduction of enamines derived from pyroglutamic acid is reported; the nature of nitrogen protection was found to be critical for the stereochemical control of the reaction outcome. Regioselective manipulation of the C-2 and C-5 substituents is possible, providing access to differently substituted pyrrolidines for a limited number of cases. The Royal Society of Chemistry 2006.