90842-69-6

Basic information

• Product Name: Ethanone, 2-(acetyloxy)-1-(4-iodophenyl)-
• Synonyms: Ethanone,2-(acetyloxy)-1-(4-iodophenyl);2-Acetoxy-1-(4-jod-phenyl)-aethanon;2-acetoxy-1-(4-iodo-phenyl)-ethanone;2'-acetoxy-4-iodoacetophenone;Essigsaeure-(4-jod-phenacylester)
• CAS NO: 90842-69-6
• Molecular Formula: C10H9IO3
• Molecular Weight: 304.084
• Mol File: 90842-69-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(acetyloxy)-1-(4-iodophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(acetyloxy)-1-(4-iodophenyl)-(90842-69-6)
• EPA Substance Registry System: Ethanone, 2-(acetyloxy)-1-(4-iodophenyl)-(90842-69-6)

Safety Data

• Hazardous Substances Data: 90842-69-6(Hazardous Substances Data)

Upstream product

• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 31827-94-8 2-bromo-1-(4-iodophenyl)ethanone 
• 591-50-4 iodobenzene 
• 13329-40-3 4-Iodoacetophenone 
• 4209-04-5 2-chloro-1-(4-iodophenyl)ethan-1-one 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 1373120-00-3 N-(1-(4-iodophenyl)vinyl)acetamide 
• 108-24-7 acetic anhydride 

Downstream Products

• 1579992-53-2 (1S)-1-(4-((trimethylsilyl)ethynyl)phenyl)ethane-1,2-diol 
• 1579992-37-2 (1S)-1-(4-ethynylphenyl)ethane-1,2-diol 

Relevant articles and documents

NOVEL CRYSTALS OF HYDROXAMIC ACID DERIVATIVE, PRODUCTION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION

Crystals of (2S)-2-((4-((4-((1S)-1,2-dihydroxyethyl)phenyl)ethynyl)benzoyl)(methyl)amino)-N-hydroxy-N′,2-dimethylmalonamide having diffraction peaks at diffraction angles (2θ) of 3.8±0.2°, 7.7±0.2°, and 10.8±0.2°, etc., or 8.2±0.2°, 12.4±0.2°, and 13.3±0.2°, etc., in powder X-ray diffraction, a production method thereof, and a pharmaceutical composition.

PhI(OAc)2-promoted umpolung acetoxylation of enamides for the synthesis of α-acetoxy ketones

Umpolung is a fundamental concept in organic chemistry, which provides an alternative strategy for the synthesis of target compounds which were not easily accessible by conventional methods. Herein, a mild and efficient PhI(OAc)2-promoted umpolung acetoxylation reactions of enamides was developed for the synthesis of α-acetoxy ketones. The reaction tolerates a wide range of functional groups and affords α-acetoxy ketones in good to excellent yields. PhI(OAc)2 serves as a source of acetoxy in the reaction.

Iodobenzene-catalyzed α-acetoxylation of ketones. In situ generation of hypervalent (diacyloxyiodo)benzenes using m-chloroperbenzoic acid

Reported here for the first time is the iodobenzene-catalyzed α-oxidation of ketones, in which diacyloxy(phenyl)-λ3-iodanes generated in situ act as real oxidants of ketones and m-chloroperbenzoic acid serves as a terminal oxidant. Oxidation of a ketone with m-chloroperbenzoic acid in acetic acid in the presence of a catalytic amount of iodobenzene, BF3·Et2O, and water at room temperature under argon affords an α-acetoxy ketone in good yield. p-Methyl- and p-chloroiodobenzene also serve as efficient catalysts in this direct oxidation. We found that when the reaction was carried out in the absence of a catalytic amount of iodobenzene, Baeyer-Villiger oxidation of a ketone took place. It is noted that use of water and BF3·Et2O is crucial to the success of this α-acetoxylation. Copyright