90862-32-1Relevant articles and documents
Hammett ρ of reactions of MeLi with benzophenones
Maclin, Keith M.,Richey Jr., Herman G.
, p. 4370 - 4371 (2002)
Relative rates of reactions of MeLi with benzophenones in diethyl ether at 0 °C that furnish methyldiaryl-methanols were determined using slow addition of a MeLi solution to solutions containing an excess of two benzophenones. The additions exhibit a Hammett p of 0.94.
Continuous preparation of arylmagnesium reagents in flow with inline IR monitoring
Brodmann, Tobias,Koos, Peter,Metzger, Albrecht,Knochel, Paul,Ley, Steven V.
experimental part, p. 1102 - 1113 (2012/08/27)
A newly developed microscale ReactIR flow cell was used as a convenient and versatile inline analytical tool for Grignard formation in continuous flow chemical processing. The LiCl-mediated halogen/Mg exchange reaction was used for the preparation of functionalized arylmagnesium compounds from aryl iodides or bromides. Furthermore, inline IR monitoring was used for the analysis of conversion and possible byproduct formation, as well as a potential tool for elucidation of mechanistic details. The results described herein indicate that the continuous flow systems are effective for highly exothermic reactions such as the Grignard exchange reaction due to fast mixing and efficient heat transfer.
C,O-dilithiated diarylmethanols: Easy and improved preparation by naphthalene-catalysed lithiation of diaryl ketones and reactivity toward electrophiles
Guijarro,Mancheno,Yus
, p. 1327 - 1334 (2007/10/02)
The lithiation of different diaryl ketones 1 with an excess of lithium powder and a catalytic amount (8 mol %) of naphthalene in tetradrofuran at -30°C leads to the formation of the corresponding dianions of the type I, with Met=Li, which react with several electrophiles (E+=MeI, EtBr, Pr(i)CHO, PhCHO, cyclohexanone, MeCN) to give, after hydrolysis, the expected substituted diarylmethanols 2.
