908808-35-5Relevant articles and documents
PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES
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Page/Page column 6, (2009/03/07)
Disclosed are novel pyrazolo[3,4-d]pyrimidine derivatives that are inhibitors of Raf kinase. These compounds and their pharmaceutically-acceptable salts and esters are anti-proliferative agents useful in the treatment or control of proliferative disorders such as solid tumors, in particular breast tumor, colon tumor, lung tumor, prostate tumor, and melanoma. Also disclosed are a composition and a unit dose formulation comprising such a compound, or a pharmaceutically-acceptable salt or ester thereof, methods for making such compounds, and methods for using such compounds, or their pharmaceutically-acceptable salts or esters, in the treatment of proliferative disorders.
Guanosine Analogues. Synthesis of Nucleosides of Certain 3-Substituted 6-Aminopyrazolopyrimidin-4(5H)-ones as Potential Immunotherapeutic Agents
Bontems, Roger J.,Anderson, Jack D.,Smee, Donald F.,Jin, Ai,Alaghamandan, Hassan A.,et al.
, p. 2174 - 2178 (2007/10/02)
Several guanosine analogues were synthesized in the pyrazolopyrimidine ring system with various substituents at the 3-position.The new analogues prepared here include the CH3 (2-amino-3-methyl-1-β-D-ribofuranosylpyrazolopyrimidin-4(5H)-one,
