908835-49-4

Basic information

• Product Name: 28-O-benzyl 3-O-[3′,4′,6′-tri-O-acetyl-2′-deoxy-2′-phthalimido-β-D-glucopyranosyl] oleanolic ester
• Synonyms: 28-O-benzyl 3-O-[3′,4′,6′-tri-O-acetyl-2′-deoxy-2′-phthalimido-β-D-glucopyranosyl] oleanolic ester
• CAS NO: 908835-49-4
• Molecular Weight: 964.206
• Mol File: 908835-49-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 28-O-benzyl 3-O-[3′,4′,6′-tri-O-acetyl-2′-deoxy-2′-phthalimido-β-D-glucopyranosyl] oleanolic ester(CAS DataBase Reference)
• NIST Chemistry Reference: 28-O-benzyl 3-O-[3′,4′,6′-tri-O-acetyl-2′-deoxy-2′-phthalimido-β-D-glucopyranosyl] oleanolic ester(908835-49-4)
• EPA Substance Registry System: 28-O-benzyl 3-O-[3′,4′,6′-tri-O-acetyl-2′-deoxy-2′-phthalimido-β-D-glucopyranosyl] oleanolic ester(908835-49-4)

Safety Data

• Hazardous Substances Data: 908835-49-4(Hazardous Substances Data)

Upstream product

• 87190-67-8 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-O-trichloroacetimidate 
• 303114-51-4 oleanolic acid benzyl ester 
• 100-39-0 benzyl bromide 
• 172847-90-4 p-methylphenyl 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-1-thio-β-D-glucopyranoside 
• 146728-55-4 3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-(α/β)-D-glucopyranosyl trichloroacetimidate 
• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 508-02-1 Oleanolic acid 

Downstream Products

• 908835-50-7 10-(7-acetylamino-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-2H-picene-4a-carboxylic acid benzyl ester 
• 908835-48-3 28-O-benzyl-3-O-[2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl]oleanolic ester 
• 81053-26-1 aridanin 

Relevant articles and documents

Design, synthesis and cytotoxic activity of N-Modified oleanolic saponins bearing A glucosamine

A series of N-acyl, N-alkoxycarbonyl, and N-alkylcarbamoyl derivatives of 2′-deoxy-glucosyl bearing oleanolic saponins were synthesized and evaluated against HL-60, PC-3, and HT29 tumor cancer cells. The SAR studies revealed that the activity increased in order of conjugation of 2′ -amino group with carbamate > amide > urea derivatives. Lengthening the alkyl chain increased the cytotoxicity, the peak activity was found to around heptyl to nonyl substitutions. 2′-N-heptoxycarbonyl derivative 56 was found to be the most cytotoxic (IC50 = 0.76 μM) against HL-60 cells. Due to the interesting SARs of alkyl substitutions, we hypothesized that their location in the cell was different, and pursued a location study using 2′-(4″-pentynoylamino) 2′-deoxy-glucosyl OA, which suggested that these compounds distributed mainly in the cytosol.