90899-14-2Relevant articles and documents
An alternative and facile synthetic approach for the precursors of 3- and 6-aminosugar donors and study of one-pot glycosyltrasferation
Pandey, Uddav,Prasad Subedi, Yagya,Alfindee, Madher N.,Shepherd, Taylor,Tom Chang, Cheng-Wei
supporting information, p. 99 - 102 (2020/01/03)
3- and 6-aminosugars are common motifs in bioactive compounds playing pivotal roles in the bioactivity of the core molecules to which they are attached. However, de novo synthesis of 3- and 6-aminosugars and their corresponding glycosyl donors can be time
Synthesis and biological evaluation of modified 2-deoxystreptamine dimers
Coste, Gerald,Horlacher, Tim,Molina, Lidia,Moreno-Vargas, Antonio J.,Carmona, Ana T.,Robina, Inmaculada,Seeberger, Peter H.,Gerber-Lemaire, Sandrine
, p. 1759 - 1770 (2011/07/30)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs. Georg Thieme Verlag Stuttgart - New York.
Efficient preparation of a 1,3-diazidocyclitol as a versatile 2-deoxystreptamine precursor
Busscher, Guuske F.,Groothuys, Stan,De Gelder, Rene,Rutjes, Floris P. J. T.,Van Delft, Floris L.
, p. 4477 - 4481 (2007/10/03)
A synthesis route toward 2-deoxystreptamine, a common structure in many of the clinically important aminoglycosides, is presented. Starting from p-benzoquinone and cyclopentadiene, 2-deoxystreptamine is synthesized with key steps involving Pd(0)-catalyzed
