90914-08-2Relevant articles and documents
EIF4E INHIBITORS AND USES THEREOF
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Paragraph 00398; 00423, (2021/09/11)
The present invention provides compounds inhibiting elF4E activity and compositions and methods of using thereof.
Inhibitory effect of novel tetrahydropyrimidine-2(1H)-thiones on melanogenesis
Thanigaimalai,Lee, Ki-Cheul,Bang, Seong-Cheol,Lee, Jee-Hyun,Yun, Cheong-Yong,Roh, Eunmiri,Hwang, Bang-Yeon,Kim, Youngsoo,Jung, Sang-Hun
experimental part, p. 1135 - 1142 (2010/04/24)
The series of imidazoldine-2-thiones 2 and tetrahydropyrimidine-2-thiones 3 were discovered as inhibitor of α-MSH-induced melanin production in melanoma B16 cells. The primary bioassay showed that 1-(4-ethylbenzyl)-tetrahydropyrimidine-2(1H)-thione 3e (>1
Antisense modulation of MDM2 expression
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, (2008/06/13)
Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.