90919-11-2

Basic information

• Product Name: β-chloroethyl p-methylthiophenyl ketone
• Synonyms: β-chloroethyl p-methylthiophenyl ketone
• CAS NO: 90919-11-2
• Molecular Weight: 214.716
• Mol File: 90919-11-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: β-chloroethyl p-methylthiophenyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: β-chloroethyl p-methylthiophenyl ketone(90919-11-2)
• EPA Substance Registry System: β-chloroethyl p-methylthiophenyl ketone(90919-11-2)

Safety Data

• Hazardous Substances Data: 90919-11-2(Hazardous Substances Data)

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 90919-52-1 β-chloroethyl p-methylsulphonylphenyl ketone 
• 76639-93-5 (1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol 
• 1322626-20-9 (1S,2S)-3-fluoro-1-[4-(methylsulfonyl)phenyl]-2-[(benzoyl)amino]-1-propanol 
• 126428-97-5 D-(-)-threo-2-phenyl-4-(fluoromethyl)-5-(4-(methylsulfonyl)phenyl)-2-oxazoline 
• 143026-79-3 (4S,5R)-2-(dichloromethyl)-4-(fluoromethyl)-5-(4-(methylsulfonyl)phenyl)-4,5-dihydrooxazole 
• 73231-34-2 Florfenicol 

Relevant articles and documents

FLORFENICOL SYNTHESIZING METHOD

The present invention discloses a new florfenicol synthesizing method. The method synthesizes florfenicol products meeting requirements of the Drug Administration by a series of combinations of cyclization, selective reduction, fluorinated open ring, deprotection and acylation, hydroxyl sulfoacid esterified configuration converting reaction, hydrolysis reaction and the like. The synthesizing method of the present invention utilizing chiral amine closed-ring aziridine three-membered ring uses a physical separation method to repeatedly purify chiral aminoketone of high yield obtaining single R configuration, and uses selective reduction and converts the configuration to obtain florfenicol, greatly improving atom economy, while avoiding waste water pollution caused by the existing process, and greatly reducing costs for treating waste water and reducing pollution to the environment, thus lowering costs and simplifying the process. In addition, the present invention uses triethylamine hydrofluoride as a fluorinated open-ring reagent, to improve safety of a liquid reaction compared to a gas reaction and reduce corrosion of equipment, facilitating industrial production.