91012-97-4Relevant articles and documents
Novel derivatives of salicylanilide: Synthesis, characterization, PPO inhibitory activity and cytotoxicity
Chen, Hui,Fang, Hua,Fang, Meijuan,Guo, Honghui,Hong, Zhuan,Zhang, Jianyu
, (2021)
Two series of novel salicylanilide analogues (4a-4 g) and (4h-4t) were designed, synthesized, and characterized, especially the structure of compound 4q was further confirmed by single X-ray diffraction. The inhibitory activity on polyphenoloxidase (PPO)
Palladium and copper complexes with oxygen-nitrogen mixed donors as efficient catalysts for the Heck reaction
Bagherzadeh, Mojtaba,Amini, Mojtaba,Ellern, Arkady,Keith Woo
experimental part, p. 46 - 51 (2012/05/04)
A simple bidentate ligand, 2-(2′-hydroxyphenyl)-5,6-dihydro-1,3- oxazine, was readily prepared with a two-step synthesis. Two novel complexes of Pd(II) and Cu(II) with this (N,O) oxazine ligand have been prepared and the molecular structures of these complexes have been confirmed by X-ray structure analysis, NMR, IR and UV-Vis spectroscopy. These complexes efficiently catalyze the Heck reaction of aryl halides with olefins at 120 °C in 8 h. The reaction conditions for the Heck coupling of iodobenzene with styrene was optimized by varying the amount of the catalyst, reaction temperature, solvent and exogenous base.
New Antianginal Nitro Esters with Reduced Hypotensive Activity. Synthesis and Pharmacological Evaluation of 3--2H-1,3-benzoxazin-4(3H)-ones
Benedini, Francesca,Bertolini, Giorgio,Cereda, Roberta,Dona, Giancarlo,Gromo, Gianni,et al.
, p. 130 - 136 (2007/10/02)
New nitro ester 3--2H-1,3-benzoxazin-4(3H)-ones show marked inhibitory activity against ischemia-induced electrocardiographic changes, with only limited systemic hemodynamic effects, and are reported in the present study.These new nitro vasodilators are potent inhibitors of the electrocardiographic T-wave and S-T segment elevation induced by intravenous or intracoronary administration of Arg-vasopressin or methacholine in the anesthetized rat.The most active compounds are up to 300- and 600- fold more potent than glyceryl trinitrate or Nicorandil, respectively.These nitro esters relax in a concentration-dependent manner the isolated rabbit aorta, at higher concentrations (2 - 40-fold) than glyceryl trinitrate, and reduce the mean arterial blood pressure at doses 7 - 300-fold higher than those required by glyceryl trinitrate to exert a similar hypotensive effect.Remarkably, these compounds retain their anti-ischemic and hemodynamic profile after oral (po) administration.These new nitro ester derivatives, endowed with a marked antianginal activity, which is not associated with concurrent and pronounced falls in systemic blood pressure, represent the leads of a new class of selective nitrovasodilators having a preferential action on large coronary vessels, which could be clinically relevant in the treatment of coronary artery diseases.
