910123-03-4Relevant articles and documents
Compositions, methods of use, and methods of treatment
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Page/Page column 30, (2017/03/08)
Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using comp
Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase
Nichols, Derek A.,Jaishankar, Priyadarshini,Larson, Wayne,Smith, Emmanuel,Liu, Guoqing,Beyrouthy, Racha,Bonnet, Richard,Renslo, Adam R.,Chen, Yu
experimental part, p. 2163 - 2172 (2012/05/20)
The emergence of CTX-M class A extended-spectrum β-lactamases poses a serious health threat to the public. We have applied structure-based design to improve the potency of a novel noncovalent tetrazole-containing CTX-M inhibitor (Ki = 21 μM) mo
