91026-01-6

Basic information

• Product Name: 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-(phenylmethyl)-
• CAS NO: 91026-01-6
• Molecular Formula: C27H19N3O2
• Molecular Weight: 417.467
• Mol File: 91026-01-6.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-(phenylmethyl)-(91026-01-6)
• EPA Substance Registry System: 1H-Pyrrole-2,5-dione, 3,4-di-1H-indol-3-yl-1-(phenylmethyl)-(91026-01-6)

Safety Data

• Hazardous Substances Data: 91026-01-6(Hazardous Substances Data)

Upstream product

• 741253-05-4 (1H-indol-3-yl)boronic acid 
• 91026-00-5 N-benzyl-2,3-dibromo-maleimide 
• 115684-57-6 2,3-bis(1H-indol-3-yl)maleic anhydride 
• 100-46-9 benzylamine 
• 100-39-0 benzyl bromide 
• 120-72-9 indole 
• 16114-24-2 1-benzyl-3,4-dichloro-pyrrole-2,5-dione 
• 115684-55-4 N-Benzyl-3,4-di(indol-3-yl)succinimide 

Downstream Products

• 1224599-82-9 (9R)-6,7,10,11-tetrahydro-19-(phenylmethyl)-9-cyano-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione 
• 115684-55-4 N-Benzyl-3,4-di(indol-3-yl)succinimide 
• 208777-07-5 1-Benzyl-3-[1-(3-dimethylamino-propyl)-1H-indol-3-yl]-4-[1-(2-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy}-ethyl)-1H-indol-3-yl]-pyrrole-2,5-dione 
• 208777-06-4 1-Benzyl-3-[1-(3-dimethylamino-propyl)-1H-indol-3-yl]-4-(1-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethyl}-1H-indol-3-yl)-pyrrole-2,5-dione 
• 133052-90-1 bisindolylmaleimide I 

Relevant articles and documents

The spermine-bisaryl conjugate as a potent inducer of B- to Z-DNA transition

DNA containing alternating purine and pyrimidine repeats has the potential to adopt the Z-DNA structure, one of the well-studied structures besides A- and B-DNA. Despite a number of molecular models that have been proposed to explain the mechanism for B→Z transition, there is continued discussion on the mechanism and physiological role of this transition. In this study, we have found that the bis(2-naphthyl)-maleimide-spermine conjugate (3c) exhibits a remarkable ability to cause the B→Z transition of d(CGCGCG)2 at low salt concentrations. Using isothermal titration calorimetry (ITC) we show that the B→Z transition induced by 3c is both enthalpically and entropically favorable. The ligand might effect the dehydration of B-DNA, which leads to the B→Z transition. Interestingly, an intermediate CD between the B and Z forms was observed in the pH-dependent transition in the presence of the ligand. The unique structure and characteristics of the ligand designed in this investigation will be useful for the study of Z-DNA. From B to Z: The bis(2-naphthyl)maleimide-spermine conjugate shown in the figure exhibits a remarkable ability to cause the B→Z transition of d(CGCGCG)2 at low salt concentrations. A stable intermediate between the B and Z forms was observed in the presence of the ligand at about pH 8.

Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles by oxidative cyclization of bisindolylmaleimides with a rhodium(III)-copper(II) catalytic system

A novel catalytic protocol for the synthesis of a series of indolo[2,3-a]pyrrplo[3,4-c]carbazoles based on the bimetallic system RhCl 3·3H2O and Cu(OAc)2·H 2O in the presence of molecular oxygen was investigated

Pyrrole derivatives and cell death inhibitors

Bisindolylpyrrole derivatives represented by general formula [I] which are useful in inhibiting cell death and expected as being useful as preventives and remedies for the progress of various diseases in the progress and worsening of which cell death part