910299-91-1

Basic information

• Product Name: 1-{4-[2-(1-amino-2-benzyloxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one
• CAS NO: 910299-91-1
• Molecular Weight: 530.47
• Mol File: 910299-91-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-{4-[2-(1-amino-2-benzyloxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{4-[2-(1-amino-2-benzyloxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one(910299-91-1)
• EPA Substance Registry System: 1-{4-[2-(1-amino-2-benzyloxy-ethyl)-4-fluoro-phenyl]-piperazin-1-yl}-3-(2,4-dichloro-phenyl)-propan-1-one(910299-91-1)

Safety Data

• Hazardous Substances Data: 910299-91-1(Hazardous Substances Data)

Upstream product

• 2646-90-4 2,5-difluorobenzaldehyde 
• 910300-26-4 4-{2-[2-benzyloxy-1-(2-methyl-propane-2-sulfinylamino)-ethyl]-4-fluoro-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 910300-19-5 4-{4-fluoro-2-[(2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 697305-53-6 4-(4-fluoro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 910300-32-2 2-methyl-propane-2-sulfinic acid [2-benzyloxy-1-(5-fluoro-2-piperazin-1-yl-phenyl)-ethyl]-amide 

Relevant articles and documents

Arylpropionylpiperazines as antagonists of the human melanocortin-4 receptor

A series of 3-arylpropionylpiperazines were synthesized as antagonists of the melanocortin-4 receptor. Their potency was found to be increased by replacing the α-methyl substituent of the initial lead 11 with a larger s-Bu or i-Bu group. Further potency enhancement was observed when a glycine or β-alanine was incorporated onto the benzylamine. Some compounds demonstrated good potency, moderate selectivity, and oral bioavailability.