910803-63-3

Basic information

• Product Name: tert-butyl (1-phenyl-1H-tetrazol-5-ylsulfanyl)acetate
• Synonyms: tert-butyl (1-phenyl-1H-tetrazol-5-ylsulfanyl)acetate
• CAS NO: 910803-63-3
• Molecular Weight: 292.362
• Mol File: 910803-63-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (1-phenyl-1H-tetrazol-5-ylsulfanyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (1-phenyl-1H-tetrazol-5-ylsulfanyl)acetate(910803-63-3)
• EPA Substance Registry System: tert-butyl (1-phenyl-1H-tetrazol-5-ylsulfanyl)acetate(910803-63-3)

Safety Data

• Hazardous Substances Data: 910803-63-3(Hazardous Substances Data)

Upstream product

• 5292-43-3 bromoacetic acid tert-butyl ester 
• 15052-19-4 5-mercapto-1-phenyl-1H-tetrazole sodium salt 

Downstream Products

• 910803-68-8 tert-butyl α-(1-phenyl-1H-tetrazol-5-ylsulfonyl)-α-fluoroacetate 
• 910803-64-4 tert-butyl (1-phenyl-1H-tetrazol-5-ylsulfonyl)acetate 

Relevant articles and documents

Exceptionally mild, high-yield synthesis of α-fluoro acrylates

Novel achiral and chiral alkyl α-(1,3-benzothiazol-2-ylsulfonyl)- α-fluoroacetates can be readily synthesized by metalation-fluorination of (1,3-benzothiazol-2-ylsulfonyl)acetates. DBU-mediated condensations of these fluorinated synthons with aldehydes proceed in a facile manner at 0 °C or at room temperature giving high yields of α-fluoro acrylates. Ketones are unreactive under these conditions. The presence of fluorine renders the synthon substantially more reactive compared to the unfluorinated analogue. Reactivity of α-(1,3-benzothiazol-2-ylsulfonyl)-α-fluoroacetate and the Horner-Wadsworth-Emmons reagent (EtO)2P(O)CHFCOOEt has also been compared.