910818-29-0

Basic information

• Product Name: 2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-5-YLAMINE
• Synonyms: 2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-5-YLAMINE;5-Amino-2-methyl-1H-pyrrolo[2,3-b]pyridine;5-AMino-2-Methyl-7-azaind...;5-AMino-2-Methyl-7-azaindole;1H-Pyrrolo[2,3-b]pyridin-5-aMine, 2-Methyl-;2-methyl-1H-pyrrolo[2,3-b]pyridin-5-amine
• CAS NO: 910818-29-0
• Molecular Formula: C8H9N3
• Molecular Weight: 147.18
• Mol File: 910818-29-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-5-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-5-YLAMINE(910818-29-0)
• EPA Substance Registry System: 2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-5-YLAMINE(910818-29-0)

Safety Data

• Hazardous Substances Data: 910818-29-0(Hazardous Substances Data)

Usage

General Description

2-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-5-YLAMINE, also known as MPP, is a chemical compound that belongs to the class of pyrrolopyridine derivatives. It is widely used in medicinal chemistry and drug design as a building block for developing kinase inhibitors and other pharmaceutical compounds. MPP has been studied for its potential therapeutic applications in the treatment of cancer, inflammation, and other diseases. Its unique molecular structure and pharmacological properties make it a valuable tool for researchers and drug developers in the pharmaceutical industry.

Relevant articles and documents

Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor

We report herein a series of substituted N-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amines as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase. Through structure-activity relationship studies, biochemical potency, pharmacokinetics, and kinase selectivity were optimized to afford BMS-645737 (13), a compound with good preclinical in vivo activity against human tumor xenograft models.