911061-53-5

Basic information

• Product Name: 2-chloro-N-((2S,3S)-2,3-dihydroxy-3-phenylpropyl)acetamide
• Synonyms: 2-chloro-N-((2S,3S)-2,3-dihydroxy-3-phenylpropyl)acetamide
• CAS NO: 911061-53-5
• Molecular Weight: 243.69
• Mol File: 911061-53-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-((2S,3S)-2,3-dihydroxy-3-phenylpropyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-((2S,3S)-2,3-dihydroxy-3-phenylpropyl)acetamide(911061-53-5)
• EPA Substance Registry System: 2-chloro-N-((2S,3S)-2,3-dihydroxy-3-phenylpropyl)acetamide(911061-53-5)

Safety Data

• Hazardous Substances Data: 911061-53-5(Hazardous Substances Data)

Upstream product

• 133187-21-0 Methyl (S)-(+)-α-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-α-phenylacetate 
• 17199-29-0 (S)-Mandelic acid 
• 133187-22-1 (2S)-2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 4392-24-9 Cinnamyl bromide 
• 911061-51-3 C₉H₁₁N₃O₂ 
• 911061-50-2 (2R,3S)-1-bromo-3-phenylpropane-2,3-diol 
• 911061-52-4 C₉H₁₃NO₂ 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 911061-54-6 C₁₁H₁₃NO₃ 
• 847805-32-7 (+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester 
• 847805-34-9 (+)-(2S,3S)-2-[α-(2-ethoxyphenoxy)phenylmethyl]morpholine-4-carboxylic acid tert-butyl ester 
• 911061-55-7 C₁₁H₁₅NO₂ 
• 71620-89-8 (S,S)-reboxetine 

Relevant articles and documents

Stereodivergent synthesis of all the four stereoisomers of antidepressant reboxetine

Chiral amino alcohol-copper(ii) catalysts Cu-L1c and Cu-ent-L1c were utilized to promote the diastereoselective nitroaldol reactions of chiral aldehydes (S)-3 or (R)-3 with nitromethane, which respectively led to the preferential formation of certain stereoisomer for nitro diol derivatives 4. Using this catalytic protocol, all the four stereoisomers of the antidepressant reboxetine were divergently prepared. The highest overall yield of this synthetic route reached up to 30.5% from aldehyde (S)-3.