911228-42-7

Basic information

• Product Name: 4-benzyl-4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester
• Synonyms: 4-benzyl-4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 911228-42-7
• Molecular Weight: 420.508
• Mol File: 911228-42-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-benzyl-4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzyl-4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester(911228-42-7)
• EPA Substance Registry System: 4-benzyl-4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester(911228-42-7)

Safety Data

• Hazardous Substances Data: 911228-42-7(Hazardous Substances Data)

Upstream product

• 6921-34-2 benzylmagnesium chloride 
• 475095-03-5 4-(cyano-ethoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester 

Downstream Products

• 911228-43-8 benzyl 4-oxo-3,4-dihydro-1H-spiro[naphthalene-2,4'-piperidine]-1'-carboxylate 

Relevant articles and documents

General and efficient synthetic approach to novel tricyclic spiroketones

A general and efficient synthetic approach to tricyclic spiroketones of interest as useful scaffolds in drug discovery was developed. Starting from commercially available benzyl 4-oxo-1-piperidinecarboxylate (5), spirocyclic tetralone 4, spirocyclic indanone 14, and spirocyclic benzocycloheptanone 15 were synthesized via six reaction steps in excellent overall yield.

SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE

Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.