91127-04-7Relevant articles and documents
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors
Wan, Yichao,Wang, Junhua,Sun, Feng'E,Chen, Minglu,Hou, Xuben,Fang, Hao
, p. 7685 - 7693 (2015/12/20)
Anti-apoptotic proteins, such as B-cell lymphoma (Bcl-2) protein, myeloid cell leukemia sequence 1 (Mcl-1) protein, are potential targets for cancer treatment. In the studies, a series of pyrrolidine derivatives were developed as potent Mcl-1 inhibitors. The preliminary biological studies suggested that most of target compounds exhibit good abilities for targeting Mcl-1 protein. Among them, compound 21 (Ki = 0.53 μM) exhibited equal inhibitory activities towards Mcl-1 protein compared to positive control gossypol (Ki = 0.39 μM). This compound also possessed good antiproliferative activities against MDA-MB-231 and PC-3 cancer cells.
Vitamin K Dependent Carboxylation: Synthesis and Biological Properties of Tetrazolyl Analogues of Pentapeptidic Substrates
Dubois, Jooelle,Bory, Sonia,Gaudry, Michel,Marquet, Andree
, p. 1230 - 1233 (2007/10/02)
The pentapeptides Phe-Leu-X-Glu-Val and Phe-Leu-X-X-Val, where X= 4-(5H-tetrazolyl)-2-aminobutyric acid (tetrazolyl analogue of glutamic acid), were synthesized by addition of tri-n-butyltin azide to the corresponding nitrile-containing peptides.These tet
