91138-00-0 Usage
Description
5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, with the CAS number 91138-00-0, is an organic compound that plays a significant role in various chemical reactions and processes. It is characterized by its unique molecular structure, which includes a pyrazole ring fused with a phenyl group and a carboxylic acid functional group. This structure endows it with versatile reactivity and properties, making it a valuable building block in organic synthesis.
Uses
Used in Organic Synthesis:
5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in a wide range of chemical reactions, such as condensation, substitution, and rearrangement reactions, enabling the formation of complex organic molecules with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a building block for the development of new drugs. Its versatile reactivity and functional groups make it suitable for the synthesis of various drug candidates, including those with potential therapeutic applications in treating diseases such as cancer, inflammation, and infectious diseases.
Used in Agrochemical Industry:
5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and herbicides. Its unique structure and reactivity contribute to the development of novel agrochemicals with improved efficacy, selectivity, and environmental compatibility.
Used in Material Science:
In the field of material science, 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is employed in the synthesis of advanced materials with specific properties. Its incorporation into polymers, coatings, and other materials can lead to the development of new materials with improved performance characteristics, such as enhanced stability, durability, and functionality.
Used in Dye and Pigment Industry:
5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID is used as a starting material or intermediate in the synthesis of dyes and pigments. Its unique structure and reactivity enable the development of novel dyes and pigments with improved color properties, stability, and application performance in various industries, such as textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 91138-00-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,1,3 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 91138-00:
(7*9)+(6*1)+(5*1)+(4*3)+(3*8)+(2*0)+(1*0)=110
110 % 10 = 0
So 91138-00-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O2/c1-8-10(11(14)15)7-12-13(8)9-5-3-2-4-6-9/h2-7H,1H3,(H,14,15)
91138-00-0Relevant articles and documents
Structural, spectral, and theoretical investigations of 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid
Viveka, Shivapura,Vasantha, Gowda,Dinesha,Naveen, Shivalingegowda,Lokanath, Neratur Krishnappagowda,Nagaraja, Gundibasappa Karikannar
, p. 4497 - 4511 (2016)
The present research work has focused on combined experimental and theoretical studies of one of the biologically important pyrazole-4-carboxylic acid derivatives, viz. 5-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid (C11H10N2/
Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity
De Vita, Elena,Schüler, Peter,Lovell, Scott,Lohbeck, Jasmin,Kullmann, Sven,Rabinovich, Eitan,Sananes, Amiram,He?ling, Bernd,Hamon, Veronique,Papo, Niv,Hess, Jochen,Tate, Edward W.,Gunkel, Nikolas,Miller, Aubry K.
supporting information, p. 8859 - 8874 (2018/10/09)
Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.
AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF
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Paragraph 0338; 0371; 0372, (2016/10/08)
The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.
