91226-39-0Relevant articles and documents
NOVEL 5-HT2 ANTAGONISTS
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Paragraph 0124; 0125, (2017/01/05)
The present invention relates to 1-amidino-3-aryl-2-pyrazoline derivatives of the general formula I The invention specifically relates to such derivatives which exhibit antagonizing activity towards serotonin 5-HT2B receptors. The present invention also relates to use of said compounds as a medicament and for the treatment of fibrosis, cardiovascular diseases, pain, IBD, and other inflammatory diseases, as well as pharmaceutical compositions comprising one or more of said compounds and methods of treatment.
Reactions of Pyridinium Ylides with Aldehydes and with Michael Acceptors
Katritzky, Alan R.,Rubio, Olga,Aurrecoechea, Jose M.,Patel, Ranjan C.
, p. 941 - 945 (2007/10/02)
1-Methyl and 1-allyl-2,4,6-triphenylpyridinium cations react with aromatic aldehydes at the α-CH2 to give aldol products (7) and (8).The allyl adducts (8) were thermally converted into aldehydes and ketones, whereas thermolysis of (7) took a variety of courses.Zwitterions from 1-methylpyridinium cations were also added Michael-fashion to activated carbon-carbon double bonds.