912293-20-0Relevant articles and documents
Synthesis of the northern hemisphere of amphidinolide H2
Liesener, Florian P.,Jannsen, Ulrike,Kalesse, Markus
, p. 2590 - 2602 (2008/02/04)
The stereoselective synthesis of the fully functionalized northern hemisphere of the marine natural product amphidinolide H2 is described. A vinylogous Mukaiyama aldol reaction and enzymatic desymmetrization of a meso compound are the key steps in the fragment synthesis. A stereoselective acetate aldol coupling and a 1,3-anti-reduction of the resulting β-hydroxy ketone complete the synthesis of the C14-C26 fragment. Georg Thieme Verlag Stuttgart.
