91241-38-2

Basic information

• Product Name: 6-CHLORO-N4-(4-METHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE
• Synonyms: 6-CHLORO-N4-(4-METHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE;BUTTPARK 17\06-43;N-(2-AMINO-6-CHLORO-4-PYRIMIDINYL)-N-(4-METHOXYPHENYL)AMINE;6-chloro-N4-(4-methoxyphenyl)pyrimidine-2,4-diamine
• CAS NO: 91241-38-2
• Molecular Formula: C₁₁H₁₁ClN₄O
• Molecular Weight: 250.68
• Mol File: 91241-38-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 483.6°Cat760mmHg
• Flash Point: 246.3°C
• Appearance: /
• Density: 1.391g/cm³
• Vapor Pressure: 1.65E-09mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: 6-CHLORO-N4-(4-METHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-N4-(4-METHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE(91241-38-2)
• EPA Substance Registry System: 6-CHLORO-N4-(4-METHOXYPHENYL)-2,4-PYRIMIDINEDIAMINE(91241-38-2)

Safety Data

• Hazardous Substances Data: 91241-38-2(Hazardous Substances Data)

Usage

Classification

Pyrimidine derivative

Properties

Chlorine atom at the 6th position
4-methoxyphenyl group at the N4 position of the pyrimidine ring

Uses

Commonly used in pharmaceutical research and drug development
Potential therapeutic applications

Biological activities

Antitumor
Anti-inflammatory
Antifungal
Promising candidate for the development of new medications
Ongoing research to explore potential uses and mechanisms of action

InChI:InChI=1/C11H11ClN4O/c1-17-8-4-2-7(3-5-8)14-10-6-9(12)15-11(13)16-10/h2-6H,1H3,(H3,13,14,15,16)

Upstream product

• 56-05-3 2-Amino-4,6-dichloropyrimidine 
• 104-94-9 4-methoxy-aniline 

Relevant articles and documents

Heterocyclic compounds as well as preparation method and application thereof

The invention belongs to the field of medicines and particularly relates to heterocyclic compounds with the structural characteristics shown in formula (I) or pharmaceutically acceptable salts, a preparation method and an application of the heterocyclic compounds as a nucleotide oxidative damage repairase MTH1 inhibitor. Pharmacological experiment results indicate that the compounds have significant inhabitation effects on the activity of MTH1 and can be used for preventing and treating clinical diseases related to MTH1.

HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS

The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-kinase.