91246-78-5

Basic information

• Product Name: Butanoic acid, 3-[(phenylmethyl)amino]-
• CAS NO: 91246-78-5
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• Mol File: 91246-78-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 3-[(phenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 3-[(phenylmethyl)amino]-(91246-78-5)
• EPA Substance Registry System: Butanoic acid, 3-[(phenylmethyl)amino]-(91246-78-5)

Safety Data

• Hazardous Substances Data: 91246-78-5(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 507444-65-7 methyl 3-(benzylamino)butanoate 
• 1020-67-3 ethyl 3-(benzylamino)crotonate 
• 107-93-7 (E)-but-2-enoic acid 
• 623-70-1 ethyl (E)-crotonate 
• 75-07-0 acetaldehyde 
• 105-36-2 ethyl bromoacetate 
• 72687-57-1 β-benzylamino-butyronitrile 
• 3724-65-0 2-butenoic acid 
• 6335-80-4 ethyl 3-(benzylamino)butanoate 

Downstream Products

• 113034-33-6 (R)-N-benzyl-β³-homoalanine 
• 67337-75-1 (S)-N-benzyl-β³-homoalanine 
• 2835-82-7 3-aminobutyric acid 
• 99981-50-7 3-(benzylamino)butanamide 
• 4391-83-7 1-benzyl-4-methylazetidinone 

Relevant articles and documents

Chemo- And regioselective nucleophilic hydrofunctionalization of unactivated aliphatic alkenes under transition-metal-free catalysts

Transition-metal-free-catalyzed nucleophilic hydrofunctionalization of both terminal and internal unactivated aliphatic alkenes has been described for the first time. Most topical classes of carbon, nitrogen and oxygen nucleophiles are well-compatible. The highly chemoselective unprotected dinucleophiles are also presented in the atom-economical approach. More than 80 structurally complex β-hetero-substituted aliphatic amides were rapidly synthesized in good yield with exclusive Markovnikov selectivity, which are difficult to be achieved efficiently by the traditional Michael addition of conjugated amides due to their poor intrinsic electrophilicity.

Evaluation of β-Aminocarboxylic Acid Derivatives in Hippocampal Excitatory Synaptic Transmission

β-Aminocarboxylic acid derivatives (LINS04 series) were screened with the aim to explore their potential functional role in excitatory synaptic transmission in the central nervous system. We used field recordings in rat hippocampal slices to investigate the effects of the LINS04 series on the synaptic transmission at hippocampal CA1 synapses. We found that LINS04008 and LINS04009 increase the size of the evoked field excitatory postsynaptic potential (EPSP) in a dose-dependent manner. The concentration–response curve shows that the efficacy of LINS04008 is highest in the series (EC50 = 91.32 μM; maximum fEPSP 44.97%). The esters LINS04006 and LINS04005 did not affect the synaptic evoked activity. These data provide the first evidence of synaptic activity enhancement by these compounds and the importance of the acidic group to the activity. This set of data may provide direction for a strategic procedure to restore the glutamate synaptic transmission; however, further studies are needed to establish a more complete picture of how these molecules act on the glutamate transmission, which are in our mind for the next steps.

A facile synthesis of β-lactams by the cyclization of β-amino acids exploiting 3,3′-(phenylphosphoryl)-bis(1,3-thiazolidine-2-thione)

3,3′-(Phenylphosphoryl)-bis(1,3-thiazolidine-2-thione) (5), obtained from phenylphosphonic dichloride (7) and sodium salt of 1,3-thiazolidine-2-thione (6), proved to be useful for intramolecular dehydration of various β-amino acids to give the correspondi