91246-99-0

Basic information

• Product Name: 2,2-dimethyl-3-hydroxy-3-phenylpropionamide
• Synonyms: 2,2-dimethyl-3-hydroxy-3-phenylpropionamide
• CAS NO: 91246-99-0
• Molecular Weight: 193.246
• Mol File: 91246-99-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-3-hydroxy-3-phenylpropionamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-3-hydroxy-3-phenylpropionamide(91246-99-0)
• EPA Substance Registry System: 2,2-dimethyl-3-hydroxy-3-phenylpropionamide(91246-99-0)

Safety Data

• Hazardous Substances Data: 91246-99-0(Hazardous Substances Data)

Usage

General Description

2,2-dimethyl-3-hydroxy-3-phenylpropionamide is a chemical compound with a molecular formula C12H17NO2. It is a derivative of 3-hydroxy-3-phenylpropionamide, with the addition of two methyl groups on the carbon 2 position. 2,2-dimethyl-3-hydroxy-3-phenylpropionamide is commonly used as a pharmaceutical intermediate in the synthesis of various medications and can act as an inhibitor of certain enzymes. Its structure and properties make it useful in drug development and research as well as in the production of certain chemical compounds.

Upstream product

• 7391-73-3 2,2-dimethyl-3-oxo-3-phenylpropanenitrile 
• 100-52-7 benzaldehyde 
• 50654-42-7 3-hydroxy-2,2-dimethyl-3-phenylproprionitrile 
• 20769-85-1 2-bromoisobutyric acid bromide 

Relevant articles and documents

Synthesis of β-hydroxyamides through ruthenium-catalyzed hydration/transfer hydrogenation of β-ketonitriles in water: Scope and limitations

A cascade process for the straightforward one-pot conversion of β-ketonitriles into β-hydroxyamides is presented. The process, that proceeds in water employing the arene-ruthenium(II) complex [RuCl2(η6-p-cymene){P(4-C6H4F)2Cl}] as catalyst in combination with sodium formate, involves the initial hydration of the β-ketonitrile substrates to generate the corresponding β-ketoamide intermediates, which subsequently undergo the transfer hydrogenation (TH) of the carbonyl group. Employing a family of forty different β-ketonitriles, featuring diverse substitution patterns, the scope and limitations of the process have been established.

One-pot nitrile aldolization/hydration operation giving β-hydroxy carboxamides

Rhodium to the rescue: The formal aldol products of carboxamides (CONH 2) were obtained by using a RhI(OR) (R=H, Me) catalyst under essentially neutral pH and ambient conditions. This novel aldol strategy is based on the catalytic al