91260-88-7

Basic information

• Product Name: 4-{4-nitrophenyl}-2-(methylamino)-1,3-thiazole
• Synonyms: 4-{4-nitrophenyl}-2-(methylamino)-1,3-thiazole
• CAS NO: 91260-88-7
• Molecular Formula: C₁₀H₉N₃O₂S
• Molecular Weight: 235.26236
• Mol File: 91260-88-7.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-{4-nitrophenyl}-2-(methylamino)-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-nitrophenyl}-2-(methylamino)-1,3-thiazole(91260-88-7)
• EPA Substance Registry System: 4-{4-nitrophenyl}-2-(methylamino)-1,3-thiazole(91260-88-7)

Safety Data

• Hazardous Substances Data: 91260-88-7(Hazardous Substances Data)

Upstream product

• 34006-49-0 2-chloro-1-(4-nitrophenyl)ethanone 
• 598-52-7 1-(methyl)-thiourea 
• 99-81-0 4-Nitrophenacyl bromide 
• 100-19-6 (4-nitrophenyl)ethanone 
• 56177-37-8 1-(4-nitrophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 100-13-0 4-nitrostyrene 

Downstream Products

• 103783-68-2 N-Methyl-N-[4-(4-nitro-phenyl)-thiazol-2-yl]-acetamide 
• 110960-36-6 2-(N-methyl)trifluoroacetamido-4-(4-nitrophenyl)thiazole 

Relevant articles and documents

Synthesis of 2-aminothiazoles from styrene derivatives mediated by 1,3-dibromo-5,5-dimethylhydrantoin (DBH)

An efficient procedure for the synthesis of 2-aminothiazoles via DBH-mediated oxidative cyclization of styrenes and thioureas is reported. Various alkenes were successfully transformed to the corresponding 2-aminothiazoles in yields of 10–81% via a two-step one-pot manner using DBH as both the bromine source and oxidant. The method can be readily carried out in gram-scale and successfully applied to the synthesis of anti-inflammatory drug fanetizole using styrene as starting material.

Nanochitosan: A biopolymer catalytic system for the synthesis of 2-aminothiazoles

A convenient and efficient method is described for the synthesis of 2-aminothiazoles by one-pot reaction of ketone and thiourea using chitosan nanoparticles under mild condition. Nanochitosan was used as a biodegradable and green catalyst for this reaction in satisfactory yields. The attractive advantages of the present process include easy isolation of products, milder and cleaner conditions, higher purity and yields and easier work-up procedure.

Novel and expedient regioselective synthesis of 2-imino-3-methyl-2,3- dihydrothiazoles

Cyclization of α-tosyloxyacetophenones 1 and N-methylthiourea 2 in acidic medium affords a novel and expedient method to synthesize 2-imino-3-methyl-2,3-dihydrothiazoles 3 with excellent level of regiocontrol. Copyright Taylor & Francis Group, LLC.