912667-94-8

Basic information

• Product Name: 1'-pentylspiro[indeno[5,6-d][1,3]dioxole-5,3'-indole]-2',7(1'H,6H)-dione
• Synonyms: 1'-pentylspiro[indeno[5,6-d][1,3]dioxole-5,3'-indole]-2',7(1'H,6H)-dione
• CAS NO: 912667-94-8
• Molecular Weight: 363.413
• Mol File: 912667-94-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1'-pentylspiro[indeno[5,6-d][1,3]dioxole-5,3'-indole]-2',7(1'H,6H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1'-pentylspiro[indeno[5,6-d][1,3]dioxole-5,3'-indole]-2',7(1'H,6H)-dione(912667-94-8)
• EPA Substance Registry System: 1'-pentylspiro[indeno[5,6-d][1,3]dioxole-5,3'-indole]-2',7(1'H,6H)-dione(912667-94-8)

Safety Data

• Hazardous Substances Data: 912667-94-8(Hazardous Substances Data)

Upstream product

• 4290-90-8 1-pentylisatin 

Relevant articles and documents

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

Starting from the oxindole 2a identified through a high-throughput screening campaign, a series of NaV1.7 blockers were developed. Following the elimination of undesirable structural features, preliminary optimization of the oxindole C-3 and N-1 substituents afforded the simplified analogue 9b, which demonstrated a 10-fold increase in target potency versus the original HTS hit. A scaffold rigidification strategy then led to the discovery of XEN907, a novel spirooxindole NaV1.7 blocker. This lead compound, which in turn showed a further 10-fold increase in potency, represents a promising structure for further optimization efforts.