912669-99-9

Basic information

• Product Name: 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-
• CAS NO: 912669-99-9
• Molecular Formula: C20H21NO5
• Molecular Weight: 355.39
• Mol File: 912669-99-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-(912669-99-9)
• EPA Substance Registry System: 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-(912669-99-9)

Safety Data

• Hazardous Substances Data: 912669-99-9(Hazardous Substances Data)

Upstream product

• 533-31-3 Sesamol 
• 4290-90-8 1-pentylisatin 

Downstream Products

• 912656-34-9 XEN₉₀₇ 

Relevant articles and documents

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

Starting from the oxindole 2a identified through a high-throughput screening campaign, a series of NaV1.7 blockers were developed. Following the elimination of undesirable structural features, preliminary optimization of the oxindole C-3 and N-1 substituents afforded the simplified analogue 9b, which demonstrated a 10-fold increase in target potency versus the original HTS hit. A scaffold rigidification strategy then led to the discovery of XEN907, a novel spirooxindole NaV1.7 blocker. This lead compound, which in turn showed a further 10-fold increase in potency, represents a promising structure for further optimization efforts.