912807-35-3 Usage
Description
(R)-3-N-tert-butoxycarbonylaminopiperidine, commonly abbreviated as (R)-Boc-3-aminopiperidine, is a chiral chemical compound with the molecular formula C12H23NO3. It is characterized by its non-superimposable mirror image, which is a key feature of chiral compounds. (R)-3-N-tert-butoxycarbonylaminopiperidine is widely utilized in the fields of organic chemistry and pharmaceutical research, where it serves as a fundamental building block for the synthesis of a variety of pharmaceuticals, including antiviral and anticancer drugs. Additionally, it is employed as an intermediate in the production of other chemicals and as a reagent in chemical reactions. The presence of the tert-butoxycarbonyl (Boc) group on the amino group provides a protective function, enabling selective reactions with other functional groups within the molecule.
Uses
Used in Pharmaceutical Research:
(R)-3-N-tert-butoxycarbonylaminopiperidine is used as a building block for the synthesis of pharmaceuticals due to its versatile chemical properties and the protective role of the Boc group. This allows for the creation of various antiviral and anticancer drugs, contributing to the development of novel treatments for a range of diseases.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-3-N-tert-butoxycarbonylaminopiperidine is used as an intermediate in the production of other chemicals. Its unique structure and the protective Boc group facilitate selective reactions, making it a valuable component in the synthesis of a wide array of chemical compounds.
Used in Chemical Reactions as a Reagent:
(R)-3-N-tert-butoxycarbonylaminopiperidine also serves as a reagent in chemical reactions, where its protective Boc group allows for selective reactions with other functional groups. This selective reactivity is crucial for achieving specific outcomes in complex chemical syntheses, further expanding the compound's utility in research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 912807-35-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,2,8,0 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 912807-35:
(8*9)+(7*1)+(6*2)+(5*8)+(4*0)+(3*7)+(2*3)+(1*5)=163
163 % 10 = 3
So 912807-35-3 is a valid CAS Registry Number.
912807-35-3Relevant articles and documents
Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases
Büttner, Dominik,Kramer, Jan S.,Klingler, Franca-M.,Wittmann, Sandra K.,Hartmann, Markus R.,Kurz, Christian G.,Kohnh?user, Daniel,Weizel, Lilia,Brüggerhoff, Astrid,Frank, Denia,Steinhilber, Dieter,Wichelhaus, Thomas A.,Pogoryelov, Denys,Proschak, Ewgenij
, p. 360 - 372 (2017/12/18)
Pathogens, expressing metallo-β-lactamases (MBLs), become resistant against most β-lactam antibiotics. Besides the dragging search for new antibiotics, development of MBL inhibitors would be an alternative weapon against resistant bacterial pathogens. Inhibition of resistance enzymes could restore the antibacterial activity of β-lactams. Various approaches to MBL inhibitors are described; among others, the promising motif of a zinc coordinating thiol moiety is very popular. Nevertheless, since the first report of a thiol-based MBL inhibitor (thiomandelic acid) in 2001, no steps in development of thiol based MBL inhibitors were reported that go beyond clinical isolate testing. In this study, we report on the synthesis and biochemical characterization of thiol-based MBL inhibitors and highlight the challenges behind the development of thiol-based compounds, which exhibit good in vitro activity toward a broad spectrum of MBLs, selectivity against human off-targets, and reasonable activity against clinical isolates.
