91296-12-7

Basic information

• Product Name: 2-amino-1,9-dihydro-9-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purine-6-one
• Synonyms: 2-amino-1,9-dihydro-9-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purine-6-one
• CAS NO: 91296-12-7
• Molecular Formula: C11H15 N5 O3
• Molecular Weight: 0
• Mol File: 91296-12-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 656.3°Cat760mmHg
• Flash Point: 350.7°C
• Appearance: /
• Density: 1.92g/cm³
• Vapor Pressure: 4.04E-18mmHg at 25°C
• Refractive Index: 1.881
• CAS DataBase Reference: 2-amino-1,9-dihydro-9-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purine-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-1,9-dihydro-9-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purine-6-one(91296-12-7)
• EPA Substance Registry System: 2-amino-1,9-dihydro-9-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-6H-purine-6-one(91296-12-7)

Safety Data

• Hazardous Substances Data: 91296-12-7(Hazardous Substances Data)

Usage

Medical Uses

Treatment of gout and kidney stones
Reduction of uric acid production in the body
Prevention of high uric acid levels in patients undergoing cancer chemotherapy
Treatment of certain inherited enzyme disorders

Mechanism of Action

Inhibition of xanthine oxidase enzyme

Pharmacological Class

Xanthine oxidase inhibitor

Therapeutic Class

Antihyperuricemics

Form

Available in oral form

Administration

Should be taken with plenty of water to prevent kidney stones

Common Side Effects

Rash, nausea, liver problems

Contraindications

Not suitable for individuals with liver or kidney disease

InChI:InChI=1/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)6-1-5(3-17)7(18)2-6/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7+/m0/s1

Upstream product

• 91296-11-6 (+/-)-(1R*,2S*,4S*)-4-(2-amino-6-chloro-9H-purin-9-yl)-2-(hydroxymethyl)-1-cyclopentanol 

Relevant articles and documents

Synthesis and Antiviral Activity of Carbocyclic Analogues of 2'-Deoxyribofuranosides of 2-Amino-6-substituted-purines and of 2-Amino-6-substituted-8-azapurines

(+/-)-(1α,2β,4α)-4--2-hydroxycyclopentanemethanol (9) was synthesized by beginning with 2-amino-4,6-dichloropyrimidine and (+/-)-(1α,2β,4α)-4-amino-2-hydroxycyclopentanemethanol, preparing the 5- derivative of the resulting pyrimidine, and reducing the azo derivative.The carbocyclic analogue of 2-amino-6-chloropurine 2'-deoxyribofuranoside (10) was prepared from 9 and triethyl orthoformate, and the analogous 8-azapurine (11) was obtained by diazotizing 9.From 10 or 11, the carbocyclic analogues of 2'-deoxyguanosine, 2'-deoxythioguanosine, 2,6-diaminopurine 2'-deoxyribofuranoside, 2'-deoxy-8-azaguanosine, and 2,6-diamino-8-azapurine 2'-deoxyribofuranoside were prepared.All of these 2'-deoxyribofuranoside analogues were active against herpes simplex virus (types 1 and 2) replicating in cells in culture; some demonstrated potent activity.