91306-38-6

Basic information

• Product Name: 1,3-Dioxolane, 2-(1-bromoethyl)-2-(4-bromophenyl)-
• CAS NO: 91306-38-6
• Molecular Formula: C11H12Br2O2
• Molecular Weight: 336.023
• Mol File: 91306-38-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane, 2-(1-bromoethyl)-2-(4-bromophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane, 2-(1-bromoethyl)-2-(4-bromophenyl)-(91306-38-6)
• EPA Substance Registry System: 1,3-Dioxolane, 2-(1-bromoethyl)-2-(4-bromophenyl)-(91306-38-6)

Safety Data

• Hazardous Substances Data: 91306-38-6(Hazardous Substances Data)

Upstream product

• 107-21-1 ethylene glycol 
• 38786-67-3 2-bromo-1-(4-bromophenyl)propan-1-one 
• 10342-83-3 4'-Bromopropiophenone 

Downstream Products

• 91306-43-3 2-(4-Bromo-phenyl)-2-(1-phenylselanyl-ethyl)-[1,3]dioxolane 
• 91306-49-9 2-(4-Bromo-phenyl)-propionic acid 2-hydroxy-ethyl ester 

Relevant articles and documents

Application of Oxidative Aryl Migration in Organo-selenium and -tellurium Compounds to the Synthesis of 2-Arylpropanoic Acids

The ethylene acetals of aryl α-phenylseleno- and α-phenyltelluro-ethyl ketones i, Ph, Br) and 5-bromo-6-methoxy-2-naphthyl> have been prepared in 12-83percent yields by treating the corresponding α-bromo compounds with diphenyl diselenide-sodium or diphenyl ditelluride-sodium, respectively, in tetrahydrofuran-dimethylformamide under reflux for 6-10 h, during which the bromine is substituted by the PhSe or PhTe group.This substitution is not observed when the (PhM)2-NaBH4-EtOH (M=Se, Te) system which is known as a source of PhM- anion is used.Oxidation of the acetals thus formed with an excess of meta-chloroperbenzoic acid at 20-25 deg C for 1 h affords hydroxy-ethyl 2-arylpropanoates in 56-86percent yields via aryl group migration which are hydrolysed to 2-arylpropanoic acids, some of which are pharmaceutically important compounds.Overall isolated yields of 2-arylpropanoic acids are around 30-42percent based on the starting propiophenones over 5 steps.