913182-53-3Relevant articles and documents
Design and synthesis of substituted quinolines as novel and selective melanin concentrating hormone antagonists as anti-obesity agents
Warshakoon, Namal C.,Sheville, Justin,Bhatt, Ritu Tiku,Ji, Wei,Mendez-Andino, Jose L.,Meyers, Kenneth M.,Kim, Nick,Wos, John A.,Mitchell, Chrissy,Paris, Jennifer L.,Pinney, Beth B.,Reizes, Ofer,Hu, X. Eric
, p. 5207 - 5211 (2007/10/03)
A novel series of substituted quinoline analogs were designed and synthesized as potent and selective melanin concentrating hormone (MCH) antagonists. These analogs show potent (nM) activity (12a-k) with a moderate selectivity. Conversely, the conformatio