913295-42-8

Basic information

• Product Name: 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol
• Synonyms: 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol
• CAS NO: 913295-42-8
• Molecular Weight: 385.389
• Mol File: 913295-42-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol(913295-42-8)
• EPA Substance Registry System: 8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol(913295-42-8)

Safety Data

• Hazardous Substances Data: 913295-42-8(Hazardous Substances Data)

Upstream product

• 659729-09-6 4-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine 
• 624729-66-4 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol 

Downstream Products

• 913295-82-6 7-chloro-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol 
• 913295-81-5 5-chloro-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol 
• 913295-44-0 (R)-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 913295-43-9 (S)-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydro-naphthalen-2-ol 
• 913295-80-4 5-Chloro-8-(5-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol 
• 913295-79-1 5-Bromo-8-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol 

Relevant articles and documents

4-Aminopyrimidine tetrahydronaphthols: A series of novel vanilloid receptor-1 antagonists with improved solubility properties

8-(6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol (4) and analogs (5-10) were shown to be potent inhibitors of human and rat TRPV1 in vitro with increased solubility over our previous series. Synthesis, SAR, and improv