91349-96-1

Basic information

• Product Name: 1H-Indole-1-propanenitrile, 2,3-dihydro-
• Synonyms: 3-(2,3-Dihydro-indol-1-yl)-propionitrile;3-Indolin-1-yl-propionitril
• CAS NO: 91349-96-1
• Molecular Formula: C11H12N2
• Molecular Weight: 172.23
• Mol File: 91349-96-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-propanenitrile, 2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-propanenitrile, 2,3-dihydro-(91349-96-1)
• EPA Substance Registry System: 1H-Indole-1-propanenitrile, 2,3-dihydro-(91349-96-1)

Safety Data

• Hazardous Substances Data: 91349-96-1(Hazardous Substances Data)

Usage

Appearance

Colorless to light yellow liquid

Derivative

Indole

Contains

Nitrile group

Usage

Synthesis of pharmaceuticals and agrochemicals

Biological activity

Serotonin receptor antagonist

Potential role

Cancer treatment

Precursor

Synthesis of other organic compounds

Upstream product

• 120-72-9 indole 
• 4414-79-3 3-(1H-indol-1-yl)propanenitrile 
• 496-15-1 1-indoline 
• 64-19-7 acetic acid 
• 107-13-1 acrylonitrile 

Downstream Products

• 99855-02-4 3-indolin-1-yl-propionic acid 
• 61123-70-4 3-(2,3-dihydro-1H-indole-1-yl)propan-1-amine 
• 480-73-9 1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinoline 
• 111588-49-9 5-benzyl-1,2-dihydro-pyrrolo[3,2,1-ij]quinolin-6-one 

Relevant articles and documents

Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents

We describe the preparation and evaluation of novel indoline derivatives with potent antioxidant and anti-inflammatory activities for the treatment of pathological conditions associated with chronic inflammation. The indolines are substituted at position 1 with chains carrying amino, ester, amide, or alcohol groups, and some have additional substituents, Cl, MeO, Me, F, HO, or BnO, on the benzo ring. Concentrations of 1 pM to 1 nM of several compounds protected RAW264.7 macrophages against H2O2 induced cytotoxicity and LPS induced elevation of NO, TNF-α, and IL-6. Several derivatives had anti-inflammatory activity at 1/100th of the concentration of unsubstituted indoline. Four compounds with ester, amine, amide, or alcohol side chains injected subcutaneously in mice at a dose of 1 μmol/kg or less, like dexamethasone (5.6 μmol/kg) prevented LPS-induced cytokine elevation in the brain and peripheral tissues. Subcutaneous injection of 100 μmol/kg of these compounds caused no noticeable adverse effects in mice during 3 days of observation.