913689-08-4

Basic information

• Product Name: 2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid
• Synonyms: 2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid
• CAS NO: 913689-08-4
• Molecular Formula: C₂₀H₁₀F₂O₅
• Molecular Weight: 368.2872064
• Product Categories: Fluorescent Labels & Indicators, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 913689-08-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid(913689-08-4)
• EPA Substance Registry System: 2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid(913689-08-4)

Safety Data

• Hazardous Substances Data: 913689-08-4(Hazardous Substances Data)

Usage

Description

2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid is a xanthene dye that is fluorescein bearing two fluoro substituents at positions 2' and 7'. It is an intermediate used for the synthesis of 4',5'-Bis(1,3,2-dithiarsolan-2-yl)-2',7'-difluoro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one (B431935), a fluorinated biarsenical derivative.

Uses

Used in Fluorescence Probes:
2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid is used as an intermediate for the synthesis of B431935, a fluorinated biarsenical derivative, which is used as a fluorescence probe in various applications.
Used in Chemical Synthesis:
2-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic Acid is used as a key intermediate in the synthesis of complex organic compounds, particularly in the production of B431935, a fluorinated biarsenical derivative with potential applications in various fields.

Upstream product

• 85-44-9 phthalic anhydride 
• 103068-41-3 4-fluororesorcinol 
• 827020-43-9 bis(2,4-dinitrobenzenesulfonyl)-2',7'-difluorofluorescein 
• 195136-58-4 2′,7′-difluorofluorescein 
• 2105-61-5 1,2,4-trifluoro-5-nitrobenzene 
• 195136-65-3 1-Amino-2,4-dimethoxy-5-fluorobenzene 
• 195136-62-0 1-Fluoro-2,4-dimethoxy-5-nitro-benzene 

Downstream Products

• 861669-97-8 2-[3,6-bis-(2,2-dimethoxyethoxy)-2,7-difluoro-9H-xanthen-9-yl]benzoic acid 2,2-dimethoxyethyl ester 
• 861669-98-9 2-[3,6-bis-(2,2-dimethoxyethoxy)-2,7-difluoro-9H-xanthen-9-yl]benzoic acid 

Relevant articles and documents

Fat mass and obesity-associated protein (FTO) inhibitors prepared from 9-(2-carboxyphenyl) xanthene compounds and therapeutic effects thereof

The invention relates to usage of the following general formula I as a drug for diseases targeting fat mass and obesity-associated protein (FTO), and provides usage of 9-(2-carboxyphenyl) xanthene compounds in preparation of FTO inhibitors. Specifically, the invention discloses usage of the 9-(2-carboxyphenyl) xanthene compounds as shown in the formula (I), as well as derivatives and pharmaceutically acceptable salts thereof, in preparation of the FTO inhibitors or pharmaceutical compositions for treating FTO-related diseases.

SULFONATE COMPOUND AND FLUORESCENT PROBE USING THE SAME

The present invention provides a sulfonate compound, including a structure represented by a general formula (I) below, where, in the formula (I), an atomic group A-O is an atomic group that forms a fluorescent compound upon cleavage of a covalent bond between the atomic group A-O and a sulfonyl group, one or a plurality of atomic groups B-SO3- are bonded to an atomic group A, B is a ring that is substituted by one or a plurality of electron-withdrawing groups, the electron-withdrawing group is at least one selected from the group consisting of an alkyl halide group, a nitro group and a cyano group, and B may be the same or different in kind in the case where the plurality of B exist.

A design of fluorescent probes for superoxide based on a nonredox mechanism

Fluorometric detection of O2-? is performed based on desulfonylation of 3 to the corresponding fluoresceins 4 through nucleophilic substitution, and this fluorescing process is quite specific toward O2-? over H