913722-75-5

Basic information

• Product Name: 17-oxaandrost-5-ene-3β-yl p-chlorobenzoate
• Synonyms: 17-oxaandrost-5-ene-3β-yl p-chlorobenzoate
• CAS NO: 913722-75-5
• Molecular Weight: 426.983
• Mol File: 913722-75-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17-oxaandrost-5-ene-3β-yl p-chlorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 17-oxaandrost-5-ene-3β-yl p-chlorobenzoate(913722-75-5)
• EPA Substance Registry System: 17-oxaandrost-5-ene-3β-yl p-chlorobenzoate(913722-75-5)

Safety Data

• Hazardous Substances Data: 913722-75-5(Hazardous Substances Data)

Upstream product

• 53-43-0 dehydroepiandrosterone 
• 122-01-0 4-chloro-benzoyl chloride 
• 853-23-6 prasterone acetate 
• 23549-24-8 3β-acetoxy-20-hydroxyiminopregna-5,16-diene 
• 979-02-2 16-dehydropregnenolone acetate 

Downstream Products

• 1470067-85-6 16-formyl-17-chloroandrosta-5,16-diene-3β-yl-4-chlorobenzoate 
• 1470067-96-9 16-formyl-17-(1H-pyrazole-1-yl)androsta-5,16-diene-3β-yl p-chlorobenzoate 

Relevant articles and documents

Synthesis, antiproliferative activity, acute toxicity and assessment of the antiandrogenic activities of new androstane derivatives

A number of 17-oxo-5-androsten-3β-yl esters (9a-9f) and 3β-alkoxy-5-androsten-17-ones (11a-11e) were synthesized from commercially available (25R)-5-spirosten-3β-ol (Diosgenin) (4) as starting material. The synthesized compounds were evaluated for their antiproliferative activity against the prostate-specific cancer cell line DU-145, acute toxicity and effect on serum androgen levels, and compared with finasteride as positive control. Some of the compounds exhibited better cytotoxicity and antiandrogenic activity than the reference control. The detailed synthesis, spectroscopic data and biological activity of the synthesized compounds are reported.