91375-75-6Relevant articles and documents
Synthesis and anticonvulsant activity evaluation of 7-alkoxy-2, 4-dihydro-1H-benzo[b][1,2,4]triazolo[4,3-d][1,4]thiazin-1-ones in various murine experimental seizure models
Cao, Xu,Wang, Shi-Ben,Deng, Xian-Qing,Liu, Da-Chuan,Quan, Zhe-Shan
, p. 1829 - 1838 (2014/05/06)
A novel series of 7-alkoxy-2,4-dihydro-1H-benzo [b][1,2,4]triazolo[4,3-d] [1,4]-thiazin-1-ones have been synthesized and tested for their anticonvulsant activity using the maximal electroshock (MES) method. The majority of the compounds prepared were effe
Synthesis and anthelmintic activity of methyl [5(6)-(3-oxo-1,4-benzothiazin-7-yloxy)-benzimidazole]-2-carbamates
Sastry,Rao,Krishnan,Rastogi,Lovekar,Tripathi,Kondaiah,Sai
, p. 297 - 299 (2007/10/02)
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Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide
Jones,Venuti,Alvarez,Bruno,Berks,Prince
, p. 295 - 303 (2007/10/02)
Evaluation of a series of lactam heterocyclic analogues of cilostamide as inhibitors of cyclic AMP phosphodiesterase derived from both human platelets and rat heart in comparison with their corresponding methoxy-substituted heterocycles has revealed that the N-cyclohexyl-N-methyl-4-oxybutyramide side chain of 2 is an important lipophilic and/or steric pharmacophore. Attachment of this side chain to the parent heterocycle of the potent cyclic AMP phosphodiesterase inhibitor anagrelide afforded the hybrid structure RS-82856, shown to be more potent than either of its progenitors as an inhibitor of cyclic AMP phosphodiesterase or of ADP-induced platelet aggregation. The available in vitro data suggest that 1 possesses potentially useful antithrombotic and cardiotonic properties.