913816-41-8Relevant articles and documents
Synthesis and protective activity of β-glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine with alkylalicyclic and arylaliphatic aglycons
Zemlyakov,Tsikalova,Tsikalov,Chirva,Mulik,Kalyuzhin
, p. 576 - 582 (2007/10/03)
The following glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) were synthesized: β-4-tert-butylcyclohexyl MDP, β-2-(adamant-1-yl) ethyl MDP, β-2,2-diphenylethyl MDP, and β-2-(p-biphenyl)ethyl MDP. The starting peracetylated β-N-acetylglucosaminides were prepared by the oxazoline method. They were converted into 4,6-O-isopropylidene-N-acetyl-D- muramic acids, which were coupled with L-Ala-D-Glu(NH2)OBn. The target glycopeptides were obtained after their deprotection. The stimulation of the anti-infection resistance of mice against Staphylococcus aureus by the MDP glycosides was studied.