913820-71-0

Basic information

• Product Name: (4R)-4-Fluoro-D-proline
• Synonyms: (4R)-4-Fluoro-D-proline
• CAS NO: 913820-71-0
• Molecular Formula: C5H8FNO2
• Molecular Weight: 133.1209232
• Mol File: 913820-71-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4R)-4-Fluoro-D-proline(CAS DataBase Reference)
• NIST Chemistry Reference: (4R)-4-Fluoro-D-proline(913820-71-0)
• EPA Substance Registry System: (4R)-4-Fluoro-D-proline(913820-71-0)

Safety Data

• Hazardous Substances Data: 913820-71-0(Hazardous Substances Data)

Usage

General Description

(4R)-4-Fluoro-D-proline is a chemical compound that belongs to the category of proline amino acids, which are essential building blocks for proteins. Its molecular structure consists of a proline molecule with a fluorine atom attached to the fourth carbon of the ring. (4R)-4-Fluoro-D-proline is chiral, meaning it has a non-superimposable mirror image, and the (4R) designation indicates its specific three-dimensional arrangement. (4R)-4-Fluoro-D-proline may have potential uses in pharmaceutical research and drug development, particularly in the design of novel therapeutic agents or studies involving the modification of protein structures. Its unique structural properties and potential biological activities make it an interesting subject for further investigation in the field of medicinal chemistry.

Upstream product

• 132651-99-1 methyl 1-acetyl-cis-4-fluoro-L-pyrrolidin-5-one-2-carboxylate 
• 203866-13-1 (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 51-35-4 4R-4-hydroxyproline 
• 231282-75-0 (6R,7aS)-6-hydroxy-3,3-bis(trifluoromethyl)tetrahydro-pyrrolo[1,2-c]oxazol-1-one 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 203866-16-4 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate 
• 132651-95-7 Methyl 1-acetyl-4-fluoro-D-prolinate 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 156046-04-7 (5S,7R)-7-fluoro-2,2-bis(trifluoromethyl)-1-aza-3-oxabicyclo<3.3.0>octan-4-one 
• 203866-14-2 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid 
• 148429-59-8 (6S,7aS)-6-hydroxy-3,3-bis(trifluoromethyl)tetrahydro-pyrrolo[1,2-c]oxazol-1-one 
• 618-27-9 hydroxy L-proline 
• 129430-93-9 methyl (2S,4R)-4-hydroxy-1-tritylpyrrolidine-2-carboxylate 

Downstream Products

• 79108-50-2 1-Nitroso-cis-4-fluoro-L-proline 
• 203866-19-7 (2S,4S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 1612854-09-7 C₁₉H₂₄BrFN₄O₅ 
• 1612854-12-2 C₅₃H₆₂F₂N₈O₇ 
• 587888-04-8 N-tert-butoxycarbonyl-(2S,4S)-4-fluoroproline benzyl ester 

Relevant articles and documents

HETEROCYCLYL SUBSTITUTED PYRROLOPYRIDINES THAT ARE INHIBITORS OF THE CDK12 KINASE

This invention relates to compounds that are inhibitors of the CDK12 kinase. The compounds are useful in the treatment of disorders mediated by CDK12 kinase including myotonic dystrophy type 1 (DM1) and other disorders caused by the generation of RNA repeat expansion transcripts. In particular,the invention relates to compounds of the formula (I), or a pharmaceutically acceptable salts or N-oxides thereof, wherein R1a, R2, R3, R4a, R4b and R4c are as defined herein.

Fluorous synthesis of 18F radiotracers with the [ 18F]fluoride ion: Nucleophilic fluorination as the detagging process

Tag team: The flouro-detagging of flourous sulfonates by the [ 18F]fluoride ion was found to be an advantageous strategy for the preparation of various 18F-labeled prosthetic groups and known radiotracers (see picture). Fluorous solid phase extraction (FSPE) was used to separate the excess fluorous precursor from the labeled material, which suggests that traditional purification protocols such as distillation or tedious separation can be avoided. (Chemical Equation Presented).

Synthesis of n.c.a. cis- and trans-4-[18F]fluoro-L-proline, radiotracers for PET-investigation of disordered matrix protein synthesis

A radiosynthesis of n.c.a. (2S,4R)-4-[18F]fluoroproline (trans-configuration) and its diastereomer (2S,4S)-4-[18F]fluoroproline (cis-configuration) has been developed. It allows the routine production of up to 18 GBq of product for c