91420-41-6

Basic information

• Product Name: 1-Propanone, 1-(2-benzofuranyl)-2-Methyl-
• Synonyms: 1-Propanone, 1-(2-benzofuranyl)-2-Methyl-
• CAS NO: 91420-41-6
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22248
• Mol File: 91420-41-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Propanone, 1-(2-benzofuranyl)-2-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2-benzofuranyl)-2-Methyl-(91420-41-6)
• EPA Substance Registry System: 1-Propanone, 1-(2-benzofuranyl)-2-Methyl-(91420-41-6)

Safety Data

• Hazardous Substances Data: 91420-41-6(Hazardous Substances Data)

Usage

General Description

1-Propanone, 1-(2-benzofuranyl)-2-methyl- is a chemical compound also known as 2-Methyl-1-(2-benzofuranyl)propan-1-one. It is a ketone compound that is widely used in the field of organic chemistry and pharmaceutical research. This chemical is known for its diverse range of biological activities, including antifungal, insecticidal, and anti-tumor properties. Its structure contains a benzofuran ring, which gives it unique properties that make it valuable for medicinal and scientific purposes. Additionally, it is also used as a building block in the synthesis of various organic compounds and has potential applications in drug development and other pharmaceutical industries.

Upstream product

• 60981-57-9 (benzofuran-2-yl)trimethylsilane 
• 79-30-1 isobutyryl chloride 
• 271-89-6 1-benzofurane 
• 563-80-4 3-methyl-butan-2-one 
• 90-02-8 salicylaldehyde 
• 41717-28-6 2-benzofuroyl chloride 
• 67-56-1 methanol 
• 1646-26-0 1-(benzo[b]furan-2-yl)ethanone 

Downstream Products

• 1025760-20-6 benzofuran-2-carboxylic acid butyl ester 

Relevant articles and documents

Manganese catalyzed α-methylation of ketones with methanol as a C1 source

The direct α-methylation of ketones with methanol under hydrogen borrowing conditions using a well-defined manganese PN3P complex as a pre-catalyst was, for the first time, achieved. The reactions typically proceed at 120 °C for 20 h with 3 mol% pre-catalyst loading and in the presence of NaOtBu (50 mol%) as base. The scope of the reaction was extended to the α-methylation of esters.

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

AN EFFICIENT FRIEDEL-CRAFTS SYNTHESIS OF 2-ACYLBENZOFURANS

2-(Trimethylsilyl)benzofuran, available quantitatively from benzofuran itself, reacts rapidly with primary, secondary, and tertiary aliphatic carboxylic acid chlorides in the presence of titanium(IV) chloride at low temperature to afford the corresponding 2-acylbenzofurans in excellent yields.This approach offers significant synthetic advantage over existing routes to the title compounds.